Mayr's Database of Reactivity Parameters

Isothioureas

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Name Solvent Reactivity
Parameters
Classification Reference
(title or year)
HBTM (in CH2Cl2)
C16H14N2S*
dichloromethane

N  Param.: 13.45

sN Param.: 0.72
***J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x
HyperBTM (in CH2Cl2)
C19H20N2S*
dichloromethane

N  Param.: 14.96

sN Param.: 0.64
***J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x
HyperNTM
C23H22N2S*
dichloromethane

N  Param.: 14.47

sN Param.: 0.72
***ChemistryEurope 2026, 4, e202500434
10.1002/ceur.202500434
HyperPTM
C27H24N2S*
dichloromethane

N  Param.: 13.43

sN Param.: 0.79
***ChemistryEurope 2026, 4, e202500434
10.1002/ceur.202500434
tetramisole (TM) (in CH2Cl2)
C11H12N2S*
dichloromethane

N  Param.: 13.86

sN Param.: 0.68
***Angew. Chem. Int. Ed. 2025, 64, e202514865
10.1002/anie.202514865
THTP (3,5,6,7-tetrahydro-2H-thiazolo[3,2-a]pyrimidine)
*
dichloromethane

N  Param.: 14.45

sN Param.: 0.78
***J. Org. Chem. 2011, 76, 5104-5112
10.1021/jo200803x