We are always looking for talented and motivated people coming from different fields ranging from physics to chemistry and biology. Contact us if you are interested in a PostDoc, PhD, Diploma/Master thesis, or F-Praktikum position in one of the projects listed below or in any other research area presented in the research section.
- Ultrasensitive Fluorescence Methods for investigating Ligand-Receptor Interactions
- Single Molecule Studies of the Protease
Many of life's processes are controlled through signaling cascades that are triggered by the interaction of ligands with the appropriate receptors. In our research group, we develop and utilize novel fluorescence methods to investigate biological processes. The focus of the current PhD project is to adapt and apply fluorescence methods as Förster Resonance Energy Transfer or Image Correlation Spectroscopy for studying the interaction of ligands with receptors. For example, we will investigate the details of the fusion process of HIV with membranes, quantifying the interaction of the HIV envelop protein with its receptors and co-receptors and determining how many receptor molecules are necessary for fusion to occur. We are looking for exceptionally talented and motivated people interested in working on challenging projects in an interdisciplinary research area.
Proteins are dynamic machines that perform the functions of life. Using single molecule methods, in particular, single-pair Förster Resonance Energy Transfer and Fluorescence Correlation Spectroscopy, we are obtaining unprecedented insight into how these machines fold and function. Using a biophysical approach, we maximize the information we can gain from experiments on individual proteins to understand these fascinating machines. The focus of this PhD project is the functioning of the proteasome 26S, the protein responsible for digesting malfunctioning and misfolded proteins and instrumental in maintaining cellular health. With the advanced fluorescence methods available in our group, we will quantify the stability, stoichiometry and dynamics of protease complexes. We are looking for exceptionally talented and motivated people interested in working on challenging projects in an interdisciplinary research area.