Prof. Dr. Konstantin Karaghiosoff - Faculty for Chemistry and Pharmacy
Prof. Dr. Konstantin Karaghiosoff - Faculty for Chemistry and Pharmacy
Aspect of interest is the development of synthetic routes towards phosphines and phosphine oxides which contain N-heterocycles. These P-N-ligands can act as hemilabile confusing ligands (coordination over P/O and/or N) and can show diverse coordination behaviors. Focus hereby is on a cheap and easy synthesis of these ligands. The application for these compounds can either be for catalytic reactions or even luminescent materials.
Phosphonates are of great importance to medical and pharmaceutical science. They find wide application in various drugs as medicines against osteoporosis or antiviral agents (e.g. Foscarnet). Despite of these important pharmaceutical applications and despite the fact, that various metal ions are present in living systems, very little is known about the coordination properties of these phosphonates. However, knowledge and understanding of the ligand properties of the phosphonates is of great importance and is one of the main topics of our ongoing investigations on metal phosphonates.
The area of interest is based on small fluorine containing building blocks. Due to the beneficial properties of fluorine, molecules with unique properties can be synthesized. The major research focuses on the production of CFC-free fluoromethylating reagents. These reagents are studied for their ability to transfer a CH2F-group. The aim is to replace environmentally harmful reagents which are used today for the synthesis of Pharmaceutica (e.g. Fluticasone). Furthermore, the effect of a CH2F-group on the impact and friction sensitivity as well as the energetic properties will be investigated in comparison to a CH3-group in energetic molecules.
Ref.: C. Kirst, F. Zoller, T. Bräuniger, P. Mayer, D. Fattakhova-Rohlfing, K. Karaghiosoff, Inorg. Chem. 2021, DOI 10.1021/acs.inorgchem.0c03334.
Of particular interest are spin systems, in which the equivalence of two or more isochronous nuclei is canceled by the presence of different couplings to a nucleus, belonging to another element. Such spin systems may occur in the isotopomers of P,Se-heterocycles with one 77Se nucleus. Their NMR-spectra are very good examples for the application of the method of subspectral analysis. NMR-spectra measurements can also be offered as a service for other institutions or companies. Especially exotic measurements for heteroatoms like 63Cu, 65Cu, 33S, 17O or 14N, 15N can be done.
Ref.: B. Hu, X. Cheng, Y. Hu, X. Liu, K. Karaghiosoff, J. Li, Angewandte Chemie International Edition 2021, 60, 15497–15502.
Structure determination in the solid state is an essential part of materials science. Single Crystal X-Ray measurements are also offered as a service for collaborators, other institutions or companies.