Carell Group

Chair of Organic Chemistry

The Carell Group is a research group concentrating on nucleic acid chemistry at the Ludwig-Maximilians-Universität München. Our projects present a wide variety throughout the field including e.g. DNA damage and repair, DNA modifications in epigenetics and click chemistry. To achieve our goals we combine classical organic synthesis with protein biochemistry.

Top5 – Recent Publications:

C.G. Spruijt, F. Gnerlich, A.H. Smits, T. Pfaffeneder, P.W.T.C. Jansen, C. Bauer, M. Münzel, M. Wagner, M. Müller, F. Khan, H.C. Eberl, A. Mensinga, A.B. Brinkman, K. Lephikov, U. Müller, J. Walter, R. Boelens, H. van Ingen, H. Leonhardt, T. Carell^∗, M. Vermeulen^∗
Cell. 2013, 152, 1146-59.
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

C. Brandmayr, M. Wagner, T. Brückl, D. Globisch, D. Pearson, A.C. Kneuttinger, V. Reiter, A. Hienzsch, S. Koch, I. Thoma, P. Thumbs, S. Michalakis, M. Müller, M. Biel, T. Carell
Angew Chem Int Ed Engl. 2012, 51, 11162-5.
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency

T. Carell, C. Brandmayr, A. Hienzsch, M. Müller, D. Pearson, V. Reiter, I. Thoma, P. Thumbs, M. Wagner
Angew Chem Int Ed Engl. 2012, 51, 7110-31.
Structure and function of noncanonical nucleobases

S. Schiesser, B. Hackner, T. Pfaffeneder, M. Müller, C. Hagemeier, M. Truss, T. Carell
Angew Chemie Int Ed Engl. 2012, 51, 6516-20.
Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing

E. Kaya, M. Vrabel, C. Deiml, S. Prill, V.S. Fluxa, T. Carell
Angew Chemie Int Ed Engl. 2012, 51, 4466-9.
A genetically encoded norbornene amino acid for the mild and selective modification of proteins in a copper-free click reaction

Prof. Dr. Thomas Carell

Thomas.Carell at cup.nulluni-muenchen.de Phone: +49 (0)89 2180 77750
Fax: +49 (0)89 2180 77756