Carell Group

Organic and Biomolecular Chemistry


The Carell Group investigates nucleic acids (DNA and RNA) using synthetic organic chemistry, biochemistry, cell biology and mass spectrometry techniques. We see today that the canonical DNA and RNA bases are at certain time points heavily modified, thus establishing a chemical language and hence a code beyond the sequence code. These chemical modifications seem to be required to orchestrate the transcriptional activity of special genes during diverse cellular processes such as stem cell differentiation and learning. Organic synthesis is used to prepare the modified bases and subsequently solid phase techniques are implemented and developed in order to incorporate the bases into DNA and RNA oligonucleotides. Mass spectrometry is applied and new chemical technologies are developed to identify the proteins involved in writing, reading and erasing the chemical message at the bases. Biochemistry, and cell biology are utilized to further characterize the proteins. The Carell group is composed of about 30 scientists, among them are synthetic chemists, biologists, stem cell biologists and mass spectrometry experts.

please activate Java-Script

Hot Publications:

A. Perera, D. Eisen, M. Wagner, S. K. Laube, A. F. Künzel, S. Koch, J. Steinbacher, E. Schulze, V. Splith, N. Mittermeier, M. Müller, M. Biel, T. Carell, S. Michalakis
Cell Rep. 2015, 11, 1-12
TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

please activate Java-Script

K. Brunner, J. Harder, T. Halbach, J. Willibald, F. Spada, F. Gnerlich, K. Sparrer, A. Beil, L. Möckl, C. Bräuchle, K-K Conzelmann, T. Carell
Angew. Chem. Int. Ed. 2014, 10.1002/anie.201409803
Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures

please activate Java-Script

M. Tomas–Gamasa, S. Serdjukow, M. Su, M. Müller, T. Carell
Angew. Chem. Int. Ed. 2014, doi:10.1002/anie.201407854
"Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link

please activate Java-Script

T. Pfaffeneder, F. Spada, M. Wagner, C. Brandmayr, S. K. Laube, D. Eisen, M. Truss, J. Steinbacher, B. Hackner, O. Kotljarova, D. Schuermann, S. Michalakis, O. Kosmatchev, S. Schiesser, B. Steigenberger, N. Raddaoui, G. Kashiwazaki, U. Müller, C. G. Spruijt, M. Vermeulen, H. Leonhardt, P. Schär, M. Müller & T. Carell
Nat. Chem. Biol. 2014, doi:10.1038/nchembio.1532
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

please activate Java-Script

A.S. Schröder, J. Steinbacher, B. Steigenberger, F.A. Gnerlich, S. Schiesser, T. Pfaffeneder, T. Carell
Angew Chem Int Ed Engl. 2014, 53, 315-8 (selected as Hot-Paper)
Synthesis of a DNA Promoter Segment Containing All Four Epigenetic Nucleosides: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxy-2’-Deoxycytidine

please activate Java-Script

Picture follows

Prof. Dr. Thomas Carell

Thomas.Carell at cup.nulluni-muenchen.de Phone: +49 (0)89 2180 77750
Fax: +49 (0)89 2180 77756