Carell Group

Organic and Biomolecular Chemistry


The Carell Group is a research group concentrating on nucleic acid chemistry at the Ludwig-Maximilians-Universität München. Our projects present a wide variety throughout the field including e.g. DNA damage and repair, DNA modifications in epigenetics and click chemistry. To achieve our goals we combine classical organic synthesis with protein biochemistry.

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Hot Publications:

A.S. Schröder, J. Steinbacher, B. Steigenberger, F.A. Gnerlich, S. Schiesser, T. Pfaffeneder, T. Carell
Angew Chem Int Ed Engl. 2014, 53, 315-8 (selected as Hot-Paper)
Synthesis of a DNA Promoter Segment Containing All Four Epigenetic Nucleosides: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxy-2’-Deoxycytidine

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T.H. Gehrke, U. Lischke, K.L. Gasteiger, S. Schneider, S. Arnold, H.C. Müller, D.S. Stephenson, H. Zipse, T. Carell
Nat Chem Biol. 2013, doi:10.1038/nchembio.1254
Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions

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C.G. Spruijt, F. Gnerlich, A.H. Smits, T. Pfaffeneder, P.W.T.C. Jansen, C. Bauer, M. Münzel, M. Wagner, M. Müller, F. Khan, H.C. Eberl, A. Mensinga, A.B. Brinkman, K. Lephikov, U. Müller, J. Walter, R. Boelens, H. van Ingen, H. Leonhardt, T. Carell, M. Vermeulen
Cell. 2013, 152, 1146-59.
Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives

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C. Brandmayr, M. Wagner, T. Brückl, D. Globisch, D. Pearson, A.C. Kneuttinger, V. Reiter, A. Hienzsch, S. Koch, I. Thoma, P. Thumbs, S. Michalakis, M. Müller, M. Biel, T. Carell
Angew Chem Int Ed Engl. 2012, 51, 11162-5.
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency

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T. Carell, C. Brandmayr, A. Hienzsch, M. Müller, D. Pearson, V. Reiter, I. Thoma, P. Thumbs, M. Wagner
Angew Chem Int Ed Engl. 2012, 51, 7110-31.
Structure and function of noncanonical nucleobases

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Prof. Dr. Thomas Carell

Thomas.Carell at cup.nulluni-muenchen.de Phone: +49 (0)89 2180 77750
Fax: +49 (0)89 2180 77756