G. Höfner, C. Zepperitz, K. T. Wanner, 'MS Binding Assays - An Alternative to Radioligand Binding', in: K. T. Wanner, G. Höfner (Hrsg.), Mass Spectrometry in Medicinal Chemistry (Wiley-VHC, Weinheim, 2007), 247-283. ISBN: 978-3-527-31456-0
G. Höfner, K.T.Wanner, MS Binding Assays in: J. Kool, W. M.A. Niessen (Hrsg.), Analyzing Biomolecular Interactions by Mass Spectrometry (Wiley-VHC Weinheim 2015), 165-198.
178. H.A. Rudy, G. Höfner, K.T. Wanner, "Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with tricyclic cage structures in the lipophilic domain as GABA uptake inhibitors", Med. Chem. Res., 2020, in print. DOI
177. J. Andreß, G. Höfner, K.T. Wanner, "MS-based screening of small amino acid derived oxime libraries for hGAT3 inhibitors", ChemMedChem, in print. DOI
176. T.M. Ackermann, L. Allmendinger, G. Höfner, K.T. Wanner, "MS Binding Assays for Glycine Transporter 2 (GlyT2)", ChemMedChem, 2020, 15, 1-18. DOI
175. J. Gabriel, G. Höfner, K.T. Wanner, "Combination of MS binding assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1", Eur. J. Med. Chem., 2020, 206, 112598. DOI.
174. H.A. Rudy, P. Mayer, K.T. Wanner, "Synthesis of 1,5‐Ring‐Fused Imidazoles from Cyclic Imines and TosMIC – Identification of in situ Generated N ‐Methyleneformamide as a Catalyst in the van Leusen Imidazole Synthesis", EurJOC, 2020, 1-15. DOI
173. M. Böck, G. Höfner, K.T. Wanner, "N-Substituted Nipecotic Acids as (S)-SNAP-5114 Analogues with Modified Lipophilic Domains", ChemMedChem, 2020, 9, 756-771. DOI
172. J. Andreß, M. Böck, G. Höfner, K.T. Wanner "Syntehsis and biological evaluation of α- and β-hydroxy substituted amino acid derivatives as potential mGAT4 inhibitors", Med. Chem. Res. 2020, online DOI
171. M. Daerr, L. Allmendinger, G. Höfner, K.T. Wanner, "Synthesis and biological evaluation of fluorescent GAT-ligands based on asymmetric substituted BODIPY dyes", Med. Chem. Res., 2020, 29, 767–782. DOI
170. P. Zaręba, B. Gryzło, K. Malawska, K. Sałat, G.C.Höfner, A. Nowaczyk, Ł. Fijałkowski, A. Rapacz, A. Podkowa, A. Furgała, P. Żmudzki, K.T. Wanner, B. Malawska, K. Kulig, Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice, Eur. J. Med Chem. 2020, 188, 111920. DOI
169. M. Daerr, J. Pabel, G. Höfner, P. Mayer, K.T. Wanner, "Synthesis and biological evaluation of fluorescent GAT-ligands based on meso-substituted BODIPY dyes", Med. Chem. Res. 2019, 29, 301–327. DOI
168. J. Gabriel, G. Höfner, K.T. Wanner, "A Library Screening Strategy Combining the Concepts of MS Binding Assays and Affinity Selection Mass Spectrometry", Frontiers in Chemistry, 2019, 7, 665. DOI
167. H.A. Rudy, K.T. Wanner, Accessing Tricyclic Imines Comprising an 2-Azabicyclo[2.2.2]octane Scaffold by Intramolecular Hetero-Diels-Alder Reaction of 4-Alkenyl Substituted N-Silyl-1,4-dihydropyridines, Synthesis 2019, 22, 4296-4310. DOI
166. S.K. Huber, G. Höfner, K.T. Wanner, "Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1)", Bioorg. Med.Chem. 2019, 27, 2753-2763. DOI
165. M. Schaarschmidt, G.Höfner, K.T. Wanner, "Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3‐Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1", ChemMedChem 2019, 12, 1135-1151. DOI
164. S. Petz, L. Allmendinger, P. Mayer, Construction of 4-substituted 2-(pyrrolidine-3-yl)acetic acid derivatives as cyclic γ-aminobutyric acid analogues employing intermolecular [2+2]-photocycloaddition as key steps, Tetrahedron 2019, 75, 2755-2762. DOI
163. F. Kern, K.T. Wanner, Screening oxime libraries by means of Mass Spectrometry (MS) Binding Assays: Identification of new highly potent inhibitors to optimized inhibitors γ- aminobutyric acid transporter 1, Bioorg. Med. Chem. 2019, 27, 1232-1245. DOI
162. T. M. Ackermann, K. Bhokare, G. Höfner, K.T. Wanner, MS binding assays for GlyT1 based on Org24598 as nonlabelled reporter ligand, Neuropharmacology 2019, 161, 107561. DOI
161. K. Toth, G. Höfner, K.T. Wanner, Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors", Bioorg. Med. Chem. 2019, 27, 822-831. DOI
160. T. J. Hauke, G. Höfner, K.T. Wanner, "MS based screening of 5‐substituted nipecotic acid derived hydrazone libraries as ligands of the GABA transporter 1", ChemMedChem, 2019, 14, 583-593. DOI
159. S.K. Huber, G. Höfner, K.T. Wanner, "Identification of Pyrrolidine‐3‐acetic Acid Derived Oximes as Potent Inhibitors of γ‐Aminobutyric Acid Transporter 1 through Library Screening with MS Binding Assays", ChemMedChem, 2018 13, 2488-2503. DOI
158. T. J. Hauke, G. Höfner, K.T. Wanner, "Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4", Bioorg. Med. Chem, 2019, 27 , 144-152 DOI
157. S. Rappenglück, S. Sichler, G. Höfner, T. Wein, K. V. Niessen, T. Seeger, F. F. Paintner, F. Worek, H. Thiermann, K.T. Wanner, "Synthesis of a Series of Non‐Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor," ChemMedChem, 2018, 13, 2653-2663. DOI
156. T. J. Hauke, T. Wein, G. Höfner, K.T. Wanner, Novel Allosteric Ligands of γ‑Aminobutyric Acid Transporter 1 (GAT1) by MS Based Screening of Pseudostatic Hydrazone Libraries, J. Med. Chem., 2018, 61, 10310–10332. DOI
155. K. Toth, G. Höfner, K. T. Wanner, Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors, Bioorg. Med. Chem. 2018, 26, 5944-5961. DOI
154. T. Wein, K. T. Wanner, S. Rappengluck, S. Sichler, K. V. Niessen, T. Seeger, F. Worek, H. Thiermann, "New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligandbased Pharmacophore Modeling", Current Computer Aided Drug Design, 2018, 161, 104 - 109. DOI
153. S. Rappenglück, S. Sichler, G. Höfner, T. Wein, K.V. Niessen, T. Seeger, F.F. Paintner, F. Worek, H. Thiermann, K.T. Wanner, Synthesis of a Novel Series of Structurally Different MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor, ChemMedChem, 2018, 13, 1806-1816 DOI
152. T. Lutz, T. Wein, G. Höfner, J. Pabel, M. Eder, J. Dine, K.T. Wanner, Development of New Photoswitchable Azobenzene Based γ‑Aminobutyric Acid (GABA) Uptake Inhibitors with Distinctly Enhanced Potency upon Photoactivation, J.Med. Chem, 2018, 61, 6211-6235. DOI
151. K. Toth, G. Höfner, K.T. Wanner, Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors, Bioorg. Med. Chem, 2018, 26, 3668-3687. DOI
150. P. Neiens, A. De Simone, G. Höfner, K. T. Wanner, Simultaneous Multiple MS Binding Assays for the dopamine, the norepinephrine, and the serotonin transporter, ChemMedChem, 2018, 13, 453-463. DOI
149. P. Neiens, A. De Simone, A. Ramershoven, G. Höfner, L. Allmendinger, K.T. Wanner, "Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine, and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT, and hNET.", Biomedical Chromatography, 2018 , 22, e4231 DOI.
148. C. Scheffel, K. V. Niessen, S. Rappenglück, K. T. Wanner, H. Thiermann, F. Worek, T. Seeger, "Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning", Toxicol. Lett. 2018 , 293, 149-156.DOI
147. C. Scheffel, K. V. Niessen, S. Rappenglück, K. T. Wanner, H. Thiermann, F. Worek, T. Seeger, Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity—An in vitro structure-activity analysis, Toxicol. Lett., 2018, 293, 157-166. DOI
146. S. Sichler, G. Höfner, S. Rappenglück, T. Wein, K. V. Niessen, T. Seeger, F. Worek, H. Thiermann, F. F. Paintner, K. T. Wanner, Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor, Toxicol. Lett., 2018, 293, 172-183. DOI
145. T. Wein, G. Höfner, S. Rappenglück, S. Sichler, K.V. Niessen, T. Seeger, F. Worek, H. Thiermann, K.T. Wanner, Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor, Toxicol. Lett., 2018, 293, 184-189. DOI
144. K.V. Niessen, T. Seeger, S. Rappenglück, T. Wein, G. Höfner, K.T. Wanner, H. Thiermann, F. Worek: In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers, Toxicol. Lett. , 2018, 293, 190-197. DOI
143. M. Ellwart, G. Höfner, A. Gerwien, K.T. Wanner, P. Knochel, Synthesis and Bioactivity of Novel N-Benzylic and N-Phenethylic Ephedrine Derivatives, Synthesis 2017, 49, 5159-5166. DOI
142. M. Schaarschmidt, K.T. Wanner, "Synthesis of Allene Substituted Nipecotic Acids by Allenylation of Terminal Alkynes, J. Org. Chem, 2017, 82, 8371-8388 DOI.
141. M. Schuller, G. Höfner, K.T. Wanner, "Simultaneous Multiple MS Binding Assays addressing D1 and D2 Dopamine receptors", ChemMedChem 2017, 12, 1585-1594 DOI
140. S. Rappenglück, K.V. Niessen, T. Seeger, F. Worek, H. Thiermann, K.T. Wanner, "Regioselective and Transition Metal Free Addition of tertButyl Magnesium Reagents to Pyridine Derivatives – A Convenient Method for the Synthesis of 3-Substituted 4tert-Butylpyridine Derivatives", Synthesis 2017, 49, 4055-4064. DOI
139. P. Neiens, G. Höfner, K. T. Wanner, "Determination of the enantiomeric purity of the selective dopamin transporter inhibitor (+)-R-R-4-(2-benzhydryloxyethyl)-1-(4-fluorbenzyl)piperidin-3-ol", Chirality 2017, 29, 294-303. DOI
138. T. Lutz, T. Wein, G. Höfner, K.T. Wanner, "Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives with N-Arylalkynyl Substituents", ChemMedChem 2017, 12, 362-371. DOI
137. S. K. Schmidt, G. Höfner, K.T. Wanner, "Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives", Chirality 2017, 29, 48-56 DOI
136. K. Salat, A. Podkowa, N. Malikowska, F. Kern, J. Pabel, E. Wojcieszak, K. Kulig, K.T. Wanner, B. Strach, E. Wyska, "Novel, highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties", Neuropharmacology 2017, 113, 331-342. DOI
135. S. Kerscher-Hack, T. Renukappa-Gutke, G. Höfner, K.T. Wanner, "Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors", Eur. J. Med. Chem. 2016, 124, 852-880 DOI
134. G. Cattaneo, D. Ubiali, E. Calleri, M. Rabuffetti, G. Höfner, K.T. Wanner, M.C. De Morares, L. K. B. Martinelli, D. S. Santos, G. Speranza, G. Massolini, "Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase", Analytica Chimica Acta 2016, 943, 89-97. DOI
133. A. Sohail, K. Jayaraman, S. K. Venkatesan, K. Gotfryd, M. Daerr, U. Gether, C.J. Loland, K.T. Wanner, M. Freissmuth, W. Sandtner, T. Stockner, H. Sitte, "The environmental shapes the inner vestibule of LeuT", PLOS Computational Biology, 2016 DOI
132. T. Hellenbrand, G. Höfner, T. Wein, K.T. Wanner, "Synthesis of 4-substituted nipecotic acid derivatives and
their evaluation as potential GABA uptake inhibitors", Bioorg. Med. Chem. 2016, 24, 2072-2096. (DOI).
131. T. Lutz, P. Spanner, K.T. Wanner, “A general approach to substituted diphenyldiazenes”, Tetrahedron 2016, 72, 1579-1589 (DOI).
130. T. Kirmeier, R. Gopalakrishnan, V. Ganal, A.M. Werner, S. Cuboni, G. C. Rudolf, G. Höfner, K.T. Wanner, S.A. Sieber, F. Holsboer, T. Rein, F. Hausch, "Azidobupramine, a novel chemical probe to enlighten antidepressants' mode of action", PLOS one, 2016, DOI
129. T. Wein, M. Petrera, L. Allmendinger, G. Höfner, J. Pabel, K. T. Wanner, "Different Binding Modes of Small and Large Binders of GAT1", ChemMedChem, 2016, 11, 509-518 (DOI).
128. M. Petrera, T. Wein, L. Allmendinger, M. Sindelar, J. Pabel, G. Höfner, K. T. Wanner, "Development of Highly Potent GAT1 Inhibitors: Synthesis of Nipecotic Acid Derivatives by Suzuki-Miyaura Cross-Coupling Reactions", ChemMedChem, 2016, 11, 519-538 (DOI).
127. P. Neiens, G.Höfner, K.T. Wanner, "MS Binding Assays for D₁ and D₅ Dopamine Receptors", ChemMedChem, 2015, 10, 1924-1931. (DOI).
126. S. Schmitt, G. Höfner, K.T. Wanner, "Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters", ChemMedChem 2015, 10, 1498-1510. (DOI)
125. S. H. Grimm, G. Höfner, K.T. Wanner, "MS Binding Assays for the three Monoamine Transporters Employing the Triple Reuptake Inhibitor (1R,3S)-Indatraline as Native Marker", ChemMedChem, 2015, 10, 1027-1039. (DOI).
124. T. Steffan, T. Renukappa-Gutke, G. Höfner, K.T. Wanner, "Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-ylacetic acids", Bioorg. Med. Chem. 2015, 23, 1284-1306. (DOI)
123. A. Jakubowska, J. Pabel, M. Żylewski, K. T. Wanner, K. Kulig, "Asymmetric synthesis of all four stereoisomers of 1-amino-3-hydroxycyclopentanecarboxylic acid", Tetrahedron 2015, 71, 686-693. (DOI)
122. F. T. Kern, K.T. Wanner, "Generation and Screening of Oximes Libraries Addressing the Neuronal GABA Transporter GAT1", ChemMedChem. 2015, 10, 396-410. (DOI).
121. S. H. Grimm, G. Höfner, K.T. Wanner, "Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor Indatraline enabling its quantification in MS Binding Assays", Anal. Bioanal Chem 2015, 407, 471-485. (DOI).
120. S. Cuboni, C. Devigny, B. Hoogeland, A. Strasser, S. Pomplun, B. Hauger, G. Höfner, K.T. Wanner, M. Eder, A. Buschauer, F. Holsboer, F. Hausch, "Loratadine and analogs: Discovery and preliminary SAR of inhibitors of the amino acid transporter B0AT2", J. Med. Chem. 2014, 57, 9473-9479 (DOI).
119. L. Allmendinger, K.T. Wanner, Synthesis of [2H7] Indatraline, J. Labelled Compd. Radiopharm. 2014, 57, 721-724 (DOI).
118. G. Quandt, G. Höfner, J. Pabel, J. Dine, M. Eder, K. T. Wanner, "First Photoswitchable Neurotransmitter Transporter Inhibitor: Light-induced Control of γ-Aminobutyric Acid Transporter 1 (GAT1) Activity in Mouse Brain", J.Med. Chem. 2014, 57, 6809–6821 (DOI)
117. S. Schmitt, G. Höfner, K.T. Wanner, MS Transport Assays for γ-aminobutyric acid transporters – an efficient alternative for radiometric assays, Anal. Chem. 2014, 86, 7575-7583. (DOI)
116. P. Kowalczyk, K. Sałat, G. C. Höfner, M. Mucha, A. Rapacz,
A. Podkowa, B. Filipek, K. T. Wanner, K. Kulig, "Synthesis, biological evaluation and structureeactivity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides", Eur. J. Med. Chem. 2014, 83, 256-273. (DOI)
115. C. Wängler, S. Chowdhury, G. Höfner, P. Djurova, E.O. Purisima, P. Bartenstein, B. Wängler, G. Fricker, K.T. Wanner, R. Schirrmacher, Shuttle−Cargo Fusion Molecules of Transport Peptides and the hD2/3
Receptor Antagonist Fallypride: A Feasible Approach To Preserve
Ligand−Receptor Binding?. J. Med. Chem. 2014, 57, 4368-4381. (DOI)
114. T. Hellenbrand, K.T. Wanner, "Conjugate Addition of Organomagnesium Cuprates to Guvacine Derivatives", Eur. J. Org. Chem, 2014, 20, 4398-4409 (DOI)
113. C. Schmaunz, P. Mayer, K.T. Wanner, "Inter- and Intramolecular [4+2] Cycloaddition Reactions
with 4,4-Disubstituted N-Silyl-1,4-Dihydropyridines as Precursors for N-Protonated 2-Azabutadiene Intermediates", Synthesis 2014, 46, 1630-1638. (DOI)
112. P. Kowalczyk, K. Sałat, G. C. Höfner, N. Guzior, B. Filipek, K. T. Wanner, K. Kulig, “2-Substituted 4-hydroxybutanamides as potential inhibitors of gamma-aminobutyric acid transporters mGAT1–mGAT4: Synthesis and biological evaluation, Bioorg. Med. Chem. 2013, 21, 5154-5167. (DOI)
111. S. Schiesser, T. Pfaffeneder, K. Sadeghian, B. Hackner, B. Steigenberger, A.S. Schröder, J. Steinbacher, G. Kashiwazaki, G. Höfner, K.T. Wanner, C. Ochsenfeld, T. Carell, “Deamination, Oxidation and C-C bond Cleavage Reactivity of 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxycytosine”, J. Am. Chem. Soc. 2013, 135, 14593-14599. (DOI)
110. S. H. Grimm, L. Allmendinger, G. Höfner, K.T. Wanner,”Enantiopurity Determination of the Enantiomers of the Triple Reuptake Inhibitor Indatraline”, Chirality, 2013, 25, 923-933. (DOI)
109. I. Sitka, L. Allmendinger, G. Fülep, G. Höfner, K.T. Wanner, "Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors", Eur. J. Med. Chem., 2013, 65, 487-499. (DOI)
108. S. Petz, K. T. Wanner, "Synthesis of 3-Azabicyclo[3.2.0]heptane Derivatives as gamma-Aminobutyric Acid Analogues via Intermolecular [2+2] Photocycloaddition", Eur. J. Org. Chem, 2013, 19, 4017-4025. (DOI)
107. Cover Article G. Quandt, G. Höfner, K. T. Wanner, "Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors, Bioorg. Med. Chem. 2013, 21, 3363-3378. (DOI)
106. M. Sindelar, T. A. Lutz, M. Petrera, K.T. Wanner, "Focused Pseudostatic Hydrazone Libraries Screened by Mass Spectrometry Binding Assay – Optimizing Affinities towards γ-Aminobutyric Acid Transporter 1", J. Med. Chem., 2013, 56, 1323-1340. (DOI)
105. X. Zhao, J. Pabel, G. Höfner, K.T. Wanner, "Synthesis and biological evaluation of 4-
hydroxy-4-(4-methoxyphenyl)-substituted proline and pyrrolidin-2-ylacetic acid derivatives as GABA uptake inhibitors", Bioorg. Med. Chem., 2013, 2, 470–484. (DOI)
104. M. Polley, G. Höfner, K.T. Wanner, "Development and validation of an LC-ESI-MS/MS quantification method for a potential γ-aminobutyric acid transporter 3 (GAT3) marker and its application in preliminary MS binding assays", Biomed. Chromatogr., 2013, 27, 641-654. (DOI)
103. K. Salat, A. Wieckowska, K. Wieckowski, G. Höfner, J. Kaminski, K. T. Wanner, B. Malawska, B. Filipek, K. Kulig, "Synthesis and pharmacological properties of new GABA uptake inhibitors", Pharmacol. Reports, 2012, 64, 817-833.
102. Y. Zhou, S. Holmseth, C. Guo, B. Hassel, G. Höfner, H.S. Huitfeldt, K.T. Wanner, N.C. Danbolt, "Deletion of the GABA transporter 2 (GAT2, SLC6A13) gene in mice leads to changes in liver and brain taurine contents", J. Biol. Chem., 2012, 287, 35733-35746. (DOI)
101. Highlighted Paper in Nat. Chem. Biol. M. Sindelar, K.T. Wanner, "Library Screening by Means of MS Binding Assays - Exemplarily Demonstrated for a Pseudo-static Library Addressing GAT1", ChemMedChem, 2012, 7, 1678-1690. (DOI)
100. J. Pabel, M. Faust, C. Prehn, B. Wörlein, L. Allmendinger, G. Höfner, K. T. Wanner, "Development of a (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine y- aminobutyric acid transporter type 4", ChemMedChem, 2012, 7, 1245 – 1255. (DOI)
99. P. Kowalczyk, G. Höfner , K.T. Wanner, K. Kulig, "Synthesis And Pharmacological Evaluation Of New 4,4-Diphenylbut-3-Enyl Derivatives Of 4-Hydroxybutanamides As Gaba Uptake Inhibitor", Acta Poloniae Pharmaceutica, 2012, 69, 157-160.
98. L. Iovkova-Berends, C. Wängler, T. Zöller, G. Höfner, K.T. Wanner, C. Rensch, P. Bartenstein, A. Kostikov, R. Schirrmacher, K. Jurkschat, B. Wängler, "t-Bu2SiF-Derivatized D2 -Receptor Ligands: The First SiFA-Containing Small Molecule Radiotracers for Target-Specific PET-Imaging, Molecules, 2011, 16, 7458-7479. (DOI)
97. C. Schmaunz, K.T. Wanner, "Synthesis of 4,4-Disubstituted Piperidine-2-carbonitriles and Piperidine-2,6-dicarbonitriles as Precursors for New 4,4-Disubstituted Pipecolic Acid and Piperidine-2,6-dicarboxylic Acid Derivatives", Synthesis, 2011, 20, 3332-3342. (DOI)
96. E. Schaffert, G. Höfner, K.T. Wanner, "Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1–mGAT4: Synthesis and biological evaluation", Bioorg. Med. Chem., 2011, 19, 6492-6504. (DOI)
95. Very Important Paper M. Hess, G. Höfner, K.T. Wanner, "(S)- and (R)-Fluoxetine as Native Markers in MS Binding Assays Addressing the Serotonin Transporter", ChemMedChem, 2011, 6, 1900-1908. (DOI)
94. A. Müller, G. Höfner, T. Renukappa-Gutke, C. Parsons, K.T. Wanner, "Synthesis of a series of γ-amino alcohols comprising a N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists", Bioorg. Med.Chem. Lett., 2011, 21, 5795-5799. (DOI)
93. M. Hess, G. Höfner, K.T. Wanner, "Development and validation of a rapid LC-ESI-MS/MS method for quantification of fluoxetine and its application to binding assays", Anal. Bioanal. Chem, 2011, 400, 3505-3515. (DOI)
92. S. Hack, B. Wörlein, G. Höfner, J. Pabel, K.T. Wanner, "Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors", Eur. J. Med. Chem., 2011, 46, 1483-1498. (DOI)
91. S. Michalakis, X. Zong, E. Becirovic, V. Hammelmann, T. Wein, K.T. Wanner, M. Biel, "The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels", J. Neurosci., 2011, 31, 133-141. (DOI)
90. K. Kulig, A. Więckowska, K. Więckowski, J. Gajda, B. Pochwat, G. Höfner, K.T. Wanner, B. Malawska, "Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors", Eur. J. Med. Chem., 2011, 46, 183-190. (DOI)
89. C. Wängler, D. Nada, G. Höfner, S. Maschauer, B. Wängler, S. Schneider, E. Schirrmacher, K.T. Wanner, R. Schirrmacher, O. Prante, "In vitro and initial in vivo evaluation of 68Ga-labeled transferrin receptor (TfR) binding peptides as potential carriers for enhanced drug transport into TfR expressing cells", Molecular Imaging & Biology, 2011, 13, 332-341. (DOI)
88. J. Bräckow, J. Pabel, P. Mayer, K. Polborn, K. T. Wanner, "Camphoric acid derived sulfur containing bicyclic carboxylic acids as chiral auxiliaries in N-acyliminium ion chemistry", Tetrahedron, 2010, 66, 7279-7287. (DOI)
87. C. Schmaunz, J. Pabel, K.T. Wanner, "Synthesis of 5-substituted 7,8-benzomorphans by intramolecular cyclizations of N-protected 4,4-disubstituted 1,4-dihydropyridines", Synthesis, 2010, 13, 2147-2160. (DOI)
86. M.R. Faust, G. Höfner, J. Pabel, K.T. Wanner, "Azetidine Derivatives as Novel GABA Uptake Inhibitors: Synthesis, Biological Evaluation, and Structure-Activity Relationship", Eur. J. Med. Chem., 2010, 45, 2453-2466. (DOI)
85. G. Höfner, K.T. Wanner, "Using short columns to speed up LC-MS quantification in MS binding assay", J. Chromatogr., B, 2010, 878, 1356-1364. (DOI)
84. T. Wein, K. T. Wanner, "Generation of a 3D model for human GABA transporter hGAT-1 using molecular modeling and investigation of the binding of GABA", J. Mol. Model, 2010, 16, 155-161. (DOI)
83. C. A. Sperger, P. Mayer, K.T. Wanner, "Application of an Ugi type reaction to a N-silyl-4,4-disubstituted 1,4-dihydropyridine", Tetrahedron, 2009, 65, 10463-10469. (DOI)
82. G. Höfner, D. Merkel, K. T. Wanner, "MS binding assays - with MALDI towards high throughput", Chem. Med. Chem., 2009, 4, 1523-1528. (DOI)
81. C. A. Sperger, K. T. Wanner, "Regioselective addition of organomagnesium reagents to N-silyl activated nicotinic acid esters - A convenient method for the synthesis of 4,4-disubstituted 1,4-dihydronicotinates", Tetrahedron, 2009, 65, 5824–5833. (DOI)
80. J. Pabel, E. Wadenstorfer, K.T. Wanner, "Asymmetric Synthesis of Pyridol[1,2-c]pyrimidones, Zeitschrift für Naturforschung B, 2009 (64b), 6, 653–661. (Link)
79. D. Hui, K. N. Kumar, J. R. Mach, A. Srinivasan, R. Pal, X. Bao, A. Agbas, G. Höfner, K. T. Wanner, E. K. Michaelis, "A rat brain bicistronic gene with an internal ribosome entry site codes for phencyclidine binding protein with cytotoxic activity", JBC, 2009, 284, 2245-2257. (DOI)
78. M. R. Faust, C. E. Hoesl, K. T. Wanner, 'Rearrangement of Dialkyl-2-(azetidin-3-yl)propane-1,3-dioates - A Structural Revision', Heterocycles, 2008, 75, 2981-2988. (DOI)
77. M. Ege, K. T. Wanner, "Diastereoselective synthesis of β-amino acid derivatives from dihydropyridones", Tetrahedron, 2008, 64, 7273-7282. (DOI)
76. S. Šimonyiová, K. T. Wanner, "Electrocyclic Ring-Opening Reactions may Cause Failure of Enolate Alkylation of 1,4-Oxazin-2-one Based Chiral Glycine Equivalents", Tetrahedron, 2008, 64, 5107-5110. (DOI)
75. C. Zepperitz, G. Höfner, K. T. Wanner, "Expanding the Scope of MS Binding Assays to Low Affinity Markers as Exemplified for mGAT1", Anal. Bioanal. Chem., 2008, 391, 309-316. (DOI)
74. A. Kragler, G. Höfner, K. T. Wanner, "Synthesis of Aminomehtylphenol Derivatives as Inhibitors of the Murine GABA Transporters mGAT1-mGAT4", Eur. J. Med. Chem., 2008, 43, 2404-2411. (DOI)
73. E. S. Schremmer, K. T. Wanner, "Zinc Iodide as an Efficient Catalyst in the TMS-Azide Modified Passerini Reaction", Heterocycles, 2007, 74, 661-671. (DOI)
72. A. Müller, K. Polborn, K. T. Wanner, "Asymmetric Alkylation of N-Acylisoindolin-1-ones via α-Bromoimides: A Novel Route to 1-Substituted Isoindolines", J. Heterocyl. Chem., 2007, 44, 575-590. (DOI)
71. M. Ludwig, C. E. Hoesl, G. Höfner, K. T. Wanner, "Affinity of 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives to the ion channel binding site of the NMDA receptor complex", Eur. J. Med. Chem., 2006, 41, 1003-1010. (DOI)
70. J. Bräckow, K. T. Wanner, "Direct Synthesis of 4,4-Disubstituted N-Silyl-1,4-Dihydropyridines", Tetrahedron, 2006, 62, 2395-2404. (DOI)
69. G. H. Fülep, C. E. Hoesl, G. Höfner, K. T. Wanner, "New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids", Eur. J. Med. Chem., 2006, 41, 809-824. (DOI)
68. C. Zepperitz, G. Höfner, K. T. Wanner, "MS-Binding assays: kinetic, saturation and competitive experiments based on quantitation of bound marker – exemplified by the GABA transporter mGAT1", ChemMedChem, 2006, 1, 208-217. (DOI)
67. U. Meyer, P. Bisel, H. Braeuner-Osborne, U. Madsen, G. Höfner, K. T. Wanner, A. W. Frahm, "Rigid nonproteinogenic cyclic amino acids as ligands for glutamate receptors: trans-tris(homoglutamic) acids", Chirality, 2005, 17, 99-107. (DOI)
66. K. V. Niessen, G. Höfner, K. T. Wanner, "Competitive MS binding assays for Dopamine D2 receptors employing spiperone as a native marker", ChemBioChem, 2005, 6, 1769 – 1775. (DOI)
65. A. Kragler, G. Höfner, K. T. Wanner, "Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4", Eur. J. Pharmacol., 2005, 519, 43-47. (DOI)
64. G. Höfner, C. E. Hoesl, C. Parsons,G. Quack, K. T. Wanner, "NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives", Bioorg. Med. Chem. Lett., 2005, 15, 2231-2234. (DOI)
63. X. Zhao, C. Hoesl, G. Höfner, K. T. Wanner, "Synthesis and Biological Evaluation of New GABA Uptake Inhibitors Derived from Proline and from Pyrrolidine-2-acetic Acid", Eur.J. Med.Chem., 2005, 40, 231-247. (DOI)
62. U. Weber, C. Hoesl, W. Ponikwar, M. Suter, H. Nöth, K. T. Wanner, "Stereoselective Synthesis of 1-Substituted 1,2,3,4-Tetra-hydro-β-carbolines by Asymmetric Electrophilic α-amidoalkylation Reactions", Heterocycles, 2004, 63, 2747-2767. (DOI)
61. M. Ege, K. T. Wanner, "Synthesis of β-Amino Acids based on Oxidative Cleavage of Dihydropyridone", Org. Lett., 2004, 6, 3553-3556. (DOI)
60. G. Höfner, K. T. Wanner, "Evaluation of GABA Uptake in Subcellular Fractions of Bovine Frontal Cortex and Brain Stem", Neurosci. Lett., 2004, 364, 53-57. (DOI)
59. C. E. Hoesl, K. T. Wanner, "First Asymmetric Syntheses of 6-Substituted Nipecotic Acid Derivatives", Tetrahedron, 2004, 60, 307-318. (DOI)
58. Cover Article G. Höfner, K. T. Wanner, "Kompetitive Bindungsstudien leicht gemacht - mit nativem Marker und massenspektrometrischer Quantifizierung", Angew. Chem., 2003, 115, 5393-5395 (DOI)
57. M. Ludwig, K. Polborn, K. T. Wanner, “Asymmetric Synthesis of 1-Substituted 1,2,3,4-Tetrahydroisoquinolines by Asymmetric Electrophilic α-Amidoalkylation Reactions“, Heterocycles, 2003, 61, 299-326. (DOI)
56. R. Kammler, K. Polborn, K. T. Wanner, “Asymmetric Synthesis of a Tricyclic Core Structure of the Securinega Alkaloids Virosecurinine and Allosecurinine”, Tetrahedron, 2003, 59, 3359–3368. (DOI)
55. C.-J. Koch, G. Höfner, K. Polborn, K. T. Wanner,“Synthesis of the Four Stereoisomers of 1-Amino-2-(hydroxymethyl)cyclobutanecarboxylic Acid and Their Biological Evaluation as Ligands for the Glycine Binding Site of the NMDA Receptor“, Eur. J. Org. Chem., 2003, 2233-2242. (DOI)
54. C.-J. Koch, S. Šimonyiová, J. Pabel, A. Kärtner, K. Polborn, K. T. Wanner, “Asymmetric Synthesis with 6-tert-Butyl-5-methoxy-6-methyl-3,6-dihydro-2H-1,4-oxazin-2-one as a New Chiral Glycine Equivalent: Preparation of Enantiomerically Pure α-Tertiary and α-Quaternary α-Amino Acids”, Eur. J. Org. Chem., 2003, 1244-1263. (DOI)
53. C. E. Hoesl, J. Pabel, K. Polborn, K. T. Wanner, „Synthesis of Sterically Demanding 3-Silylpyridines and their Use in Asymmetric Synthesis with Chiral N-Acyliminium Ions“, Heterocycles, 2002, 58, 383 – 392. (DOI)
52. C. E. Hoesl, M. Maurus, J. Pabel, K. Polborn, K. T. Wanner, “Generation of Chiral N-Acylpyridinium Ions by Means of Silyl Triflates and their Diastereoselective Trapping Reaction: Formation of N-Acyldihydropyridines and N-Acyldihydropyridones”, Tetrahedron, 2002, 58, 6757–6770. (DOI)
51. J. Pabel, C. E. Hösl, M. Maurus, M. Ege, K. T. Wanner, "Generation of N-Acylpyridinium Ions from Pivaloyl Chloride and Pyridine Derivatives by Means of Silyl Triflates", J. Org. Chem., 2000, 65, 9272-9275. (DOI)
50. J. Pabel, G. Höfner, K. T. Wanner, "Synthesis and Resolution of Racemic Eliprodil and Evaluation of the Enantiomers of Eliprodil as NMDA Receptor Antagonists.", Bioorg. Med. Chem. Lett., 2000, 10, 1377-1380. (DOI)
49. G. Höfner, K. T. Wanner, "[3H]Ifenprodil Binding to NMDA-Receptors in Porcine Hippocampal Brain Membranes.", Eur. J. Pharmacol., 2000, 394, 211-219. (DOI)
48. O. Achatz, A. Grandl, K. T. Wanner, "Asymmetric Synthesis Employing a Chiral 5-Methoxy-1,4-oxazin-2-one Derivative: Preparation of Enantiomerically Pure α-Quaternary α-Amino Acids.", Eur. J. Org. Chem., 1999, 1967-1978. (DOI)
47. C. E. Hösl, K. T. Wanner, "Syntheses of 4-Silyl-substituted Methyl Nicotinates via Silylcupration of N-Acylpyridinium Salts", Heterocycles, 1998, 48, 2653-2659. (DOI)
46. K. T. Wanner, H. Beer, G. Höfner, M. Ludwig, "Asymmetric Synthesis and Enantioselectivity of Binding of 1-Aryl-1,2,3,4-Tetrahydroisoquinolines at the PCP Site of the NMDA-Receptor Complex.", Eur. J. Org. Chem., 1998, 2019-2029. (DOI)
45. I. Stroetmann, G. Seitz, K. T. Wanner, G. Höfner, "Syntheses of Novel Pyrazolomorphinans and their Binding to µ- and κ-Opioid-Receptors.", Pharmazie, 1998, 53, 87-90.
44. Th. Klindert, I. Stroetmann, G. Seitz, G. Höfner, K. T. Wanner, G. Frenzen und B. Eckhoff, "Syntheses of Novel Pyridazinomorphinans by Inverse Electron Demand Cycloaddition and their Binding to µ and κ Receptors.", Arch. Pharm. Pharm. Med. Chem., 1997, 330, 163-168. (DOI)
43. M. Ludwig, H. Beer, H. Lotter, K. T. Wanner, "The Absolute Configuration of (1S)-(+)- and (1R)-(-)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline. A Revision of the Literature Assignment.", Tetrahedron: Asymmetry, 1997, 8, 2693-2695. (DOI)
42. G. Höfner, K. T. Wanner, "Characterisation of the binding of [3H]MDL 105,519, a radiolabelled antagonist for the N-methyl-D-Aspartate-associated glycine site, to pig cortical brain membranes", Neurosci. Lett., 1997, 226, 79-82. (DOI)
41. K. T. Wanner, U. Weber, "A Convenient Synthesis of 1,3-Oxazolidin 4-ones and 1,3 Oxazine-4-ones", J. Heterocycl. Chem., 1997, 34 , 681-683. (DOI)
40. G. Höfner, K. T. Wanner, "Characterisation of [3H]MK-801 binding and its cooperative modulation by pig brain membranes", J. of Recept. Signal Transduction Research, 1996, 16 (5&6), 297-313. (DOI)
39. K. Görlitzer, I.-M. Weltroski, K. T. Wanner, G. Höfner, "Mannich-Basen von Morphinen, Isomorphinen und Chlormorphiden", Scientia Pharmaceutica, 1996, 64, 391-398.
38. K. T. Wanner, F. Paintner, "Asymmetrische Elektrophile α-Amidoalkylierung-11: Neue chirale Hilfsgruppen aus (+)-Camphersäure", Liebigs Ann., 1996, 1941-1948. (DOI)
37. K. T. Wanner, I. Praschak, G. Höfner, H. Beer, "Asymmetric Synthesis and Enantiospecifity of Binding of 2-(1,2,3,4-Tetrahydro-1-isoquinolyl)-ethanol-Derivatives to m and k Receptors", Arch. Pharm., 1996, 329, 11-22. (DOI)
36. U. Weber, K. T. Wanner, "Einstufige Synthese von Oxazolo[3',2':1,2]pyrido[3,4-b]indolen durch direkte Kondensationsreaktionen von 3,4-Dihydro-β-carbolin mit α-Hydroxy-α-butyrolactonen", Zeitschrift f. Naturforschung, 1995, 50b, 677-680.
35. F. Eiden, E. Reimann, H.-D. Stachel, H. Wagner, K. T. Wanner, M. H. Zenk, "Zusammenraufen oder auseinandersetzen.", PZ, 1995, 140, 2568-2570.
34. F. Eiden, E. Reimann, H.-D. Stachel, H. Wagner, K. T. Wanner, M. H. Zenk, "Anleitung zum Ruinieren eines angesehenen Berufsstandes", PZ, 1995, 140, 1108-1111.
33. K. T. Wanner, F. Paintner, "Asymmetric Electrophilic α-Amidoalkylation (AEaA), 10: A New Camphorimide Derived Chiral Auxiliary for the Asymmetric Synthesis with N-Acyliminium Ions - Preparation of Aracemic 2-Substituted Piperidines", Tetrahedron, 1994, 50, 3113-3122. (DOI)
32. K. T. Wanner, U. Weber, "Oxazolo[3',2':1,2]pyrido[3,4 b]indole und [1,3]-Oxazino[3',2':1,2]pyrido[3,4-b]indole durch eine einfache Kondensationsreaktion von 3,4- Dihydro-β-carbolin mit α- bzw. β-Hydroxycarbonsäuren, Synthesis,1994, 4, 387-390. (DOI)
31. K. T. Wanner, "Chiral N-acyliminium ions as new tools in the asymmetric synthesis of CNS-active compounds", Eur. J. Pharm. Sci., 1994, 2,62-64. (DOI)
30. K. T. Wanner, St. Stamenitis, "Asymmetrische Synthesen mit chiralen 1,4-Oxazin-2,5-dionen: Darstellung enantiomerenreiner 2-substituierter Pipecolinsäurederivate", Liebigs Ann. Chem., 1993, 477-484. (DOI)
29. K. T. Wanner, C. Wolf, "Elektrophile α-Amidoalkylierung mit Enamiden nach einem neuen Aktivierungsverfahren mit O,O´ Dimethyldithiophosphorsäure", Arch. Pharm., 1993, 326, 799-802. (DOI)
28. K. T. Wanner, E.Wadenstorfer, A. Kärtner, "Asymmetric Electrophilic Amidoalkylation, 9: Highly Stereoselective Syntheses of 2-Substituted Piperidines", Synlett, 1991, 797-799. (DOI)
27. K. T. Wanner, G.Höfner, "Chelat- und Nicht-Chelat kontrollierte Reduktionen von β-Amidoketonen: Synthese nicht-racemischer 1,3-Aminoalkohole mit Pyrrolidinstruktur", Tetrahedron, 1991, 47, 1895-1910. (DOI)
26. K. T. Wanner, G. Höfner, "Konfigurationsbestimmung von (2S,7aR)-und (2S,7aS)-2- Benzyl-5,6,7,7α -tetrahydropyrrolo[2,1-b]oxazol-3(2H)-on", Arch.Pharm., 1991, 324,191-193. (DOI)
25. K. T. Wanner, G. Höfner, "Asymmetrische Elektrophile α-Amidoalkylierung 8: Gewinnung optisch aktiver α-Phenacylpyrrolidinamide und erste asymmetrische Totalsynthese des Norruspolins", Arch. Pharm., 1990, 323, 977-986. (DOI)
24. K. T. Wanner, I. Praschak, U. Nagel, "Asymmetric Electrophilic α-Amidoalkylation 7: Generation, Chrystal Structure and Trapping Reactions of a Chiral 6,7-Dimethoxy-1,2,3,4-tetra-hydroisoquinoline Derived N-Acyliminium Ion", Arch. Pharm., 1990, 323, 335-350. (DOI)
23. K. T. Wanner, I. Praschak, "Asymmetric Electrophilic α-Amidoalkylation 6: Syntheses of Tetrahydroisoquinolines of High Enantiomeric Purity", Heterocycles, 1989, 29, 29-33. (DOI)
22. K. T. Wanner, G. Höfner, "Asymmetrische Elektrophile α-Amidoalkylierung 4: Erzeugung und Abfangreaktionen chiraler N-Acylpyrrolidiniumionen", Arch. Pharm., 1989, 322, 99-103. (DOI)
21. K. T. Wanner, G. Höfner, "Asymmetrische Elektrophile α-Amidoalkylierung 3: Synthesen von Vorstufen für die Erzeugung chiraler N-Acylpyrrolidiniumionen", Arch. Pharm., 1989, 322, 93-97.
(DOI)
20. K. T. Wanner, A. Kärtner, "Neue chirale Hilfsgruppen: Herstellung optisch aktiver Cyclopentancarbonsäuren aus (-)-Camphansäure", Synthesis, 1988, 968-970. (DOI)
19. K. T. Wanner, A. Kärtner, E. Wadenstorfer,"Asymmetric Electrophilic α-Amidoalkylation 5: Improved Stereoselectivities Through New Chiral Auxiliaries", Heterocycles, 1988, 27, 2549-2556. (DOI)
18. K. T. Wanner, "Neue chirale Hilfsgruppen: Gewinnung einer phenylazaanalogen Camphansäure nach veränderter N/O-Regioselektivität einer Ringverengungsreaktion", Liebigs Ann. Chem., 1988, 603-604.
(DOI)
17. K. T. Wanner, "Synthesen und Ringverengungsreaktionen α-halogenierter N-Phenylcamphersäureimide", Arch. Pharm., 1988, 321, 353-356. (DOI)
16. K. T. Wanner, "Tetrahydro-3-pyranon: Die Regioselektivität bei der Bildung reaktiver Intermediate", Arch. Pharm., 1988, 321, 81-83. (DOI)
15. K. T. Wanner, A. Kärtner, "Asymmetrische α-Amidoalkylierung. Synthesen enantiomerenreiner, α-substituierter Piperidine mit 1-Camphanoyl-1,2,3,4 tetrahydropyridin", Arch. Pharm., 1987, 320, 1253-1267.
14. K. T. Wanner, A. Kärtner, "Pd/C-katalysierte Doppelbindungisomerisierung von N-Acylallylaminen zu N-Acylenaminen", Arch. Pharm., 1987, 320, 1050-1058.
13. K. T. Wanner, J. Schünemann, "Synthesen optisch aktiver Oxazolo [3,2-a]piperidine via Enamide", Arch. Pharm., 1987, 320, 1161-1167.
12. K. T. Wanner, A. Kärtner, "Asymmetric α-Amidoalkylation. Synthesis of α-Substituted Piperidines of High Enantiomeric Purity", Heterocycles, 1987, 26, 921-924. (DOI)
11. K. T. Wanner, A. Kärtner, "Isomerization of N-Acyl-1,2,5,6 Tetrahydropyridines to N-Acylenamines by Palladium on Carbon", Heterocycles, 1987, 26, 917-919. (DOI)
10. A. I. Meyers, B. A. Lefker, K. T. Wanner, R. A. Aitken, "An Asymmetric Synthesis of Chiral 4,4-Disubstituted Cyclohexanones in High Enantiomeric Purity", J. Org. Chem., 1986, 51, 19361938. (DOI)
9. A. I. Meyers, R. Hanreich, K. T. Wanner, "Efficient Asymmetric Synthesis of (+)-Mesembrine and Related Chiral 4,4-Disubstituted Cylohexanones", J. Am. Chem. Soc., 1985,107, 7776-7778. (DOI)
8. A. I. Meyers, K. T. Wanner, "Chiral Quaternary Carbon Compounds, II. An Asymmetric Synthesis of (R) or (S)-4,4-Dialkyl-2-Cyclopentenones", Tetrahedron Lett., 1985, 26, 2047-2050. (DOI)
7. K. T. Wanner, A. Kärtner, "Cyclobutanon-Enamine: Synthese und Reaktionen des (1-Cyclobutenyl)piperidins", Arch. Pharm., 1985, 318, 655-658. (DOI)
6. F. Eiden, W. Winkler, K. T. Wanner, A. Markhauser, "Zentralwirksame 4- Phenylpyrane: Hydrierte Phenylchromene, Phenylaza- und Phenyloxachromene sowie Phenyloxa- und Phenyldioxaxanthene durch [4+2]-Cycloaddition", Arch. Pharm., 1985, 318, 648-655. (DOI)
5. F. Eiden, K. T. Wanner, "5,6-Dihydro-2-H-pyran-3(4H)-on als Baustein zur Synthese pyrananellierter Heterocyclen", Liebigs Ann. Chem., 1984, 1759-1777. (DOI)
4. F. Eiden, K. T. Wanner, "Pyrano- und Naphthopyrano[3,2-b]indol Derivate", Arch. Pharm., 1985, 318, 648-655. (DOI)
3. F. Eiden, K. T. Wanner, "Regiospezifische Synthese von 2 Phenylpyrano-[3,4-b]pyranonen (Oxaflavon-Derivaten) mit Tetrahydro-3-pyranon", Arch. Pharm., 1985, 318, 207-209. (DOI)
2. K. T. Wanner, F. Eiden, "Benzothiazole durch C-C-Spaltung von α-[(2-Nitrophenyl)-thio]ketonen", Liebigs Ann. Chem., 1984, 1100-1108. (DOI)
1. F. Eiden, K. T. Wanner, "Tetrahydro-3-pyranon als Baustein zur Pyrano[3,2-b]pyran- Synthese", Arch. Pharm., 1984, 317, 958-962. (DOI)
3. Wanner, Klaus; Höfner, Georg; Bertling, Wolf; Kosak, Hans. “Method for the determining the binding behaviour of ligands which specifically bind to target molecules”. PCT Int. Appl. (2002), 44 pp. CODEN: PIXXD2 WO 2002095403 A2 20021128.
2. Wanner, Klaus; Höfner, Georg; Bertling, Wolf. “Method for determining the quantity of ligands that are bound to target molecules.“ PCT Int. Appl. (2001), 39 pp. CODEN: PIXXD2 WO 2001094943 A2 20011213 .
1. Wanner, Klaus; Fuelep, Guenther; Höfner, Georg. “GABA-uptake-Inhibitoren mit Pyrrolidinstruktur”. Ger. Offen. (2000), 36 pp. CODEN: GWXXBX DE 19840611 A1 20000309.