Virus LMU CENS BIN

Dr. Viola Baumgärtel


"The true sign of intelligence is not knowledge but imagination." (Albert Einstein)
"Measure what is measurable, and make measurable what is not so." (Galileo Galilei)


Research project

My main research focus lies in the understanding of dynamic cellular processes involved in the HIV-1 replication cycle (entry, integration, budding, maturation) by using quantitative live-cell imaging, single virus tracking and high resolution microscopy. By applying different fluorescence imaging techniques (TIRF wide field, FCS, STORM), I intend to elucidate the underlying molecular and biophysical mechanisms especially in HIV-1 budding and release.

In the future I would like to expand the focus of my research towards other retroviruses and work on the development of new image analysis methods. Apart from that, I do have a deep fascination for understanding the exact temporal and spatial order of cellular events as well as for reproducing in vivo processes on the basis of tissue or blood flow models. This is one reason, why I love to work in interdisciplinary fields at the border of many disciplines like physics, biology, bio- and nanotechnology.

Qualifications

Quantitative Fluorescence Microscopy, Live-cell Imaging, Image Analysis, Programming, Cell Biology, Protein Biochemistry, Single Virus Tracking, Kinetic Studies, Image Correlation Spectroscopy

Competence in Leadership & Teaching, Center for Leadership & People Management, Munich; http://www.peoplemanagement.uni-muenchen.de/index.html


Curriculum Vitae

2009-present Postdoctoral fellow, Ludwig-Maximilians University Munich, Department of Chemistry (Prof. Don C. Lamb)
2005-2008 PhD in Biochemistry, Center for Nanotechnology (CeNTech), University Clinic Muenster, Department of Medical Physics & Biophysics (Prof. Reiner Peters), Thesis: Kinetic study of nucleocytoplasmic transport receptors and retroviral RNA substrates
2004 Internship, Natural & Medical Sciences Institute (NMI), Reutlingen (Dr. Martin Stelzle), Project: Planning & design of microfluidic devices for drug delivery in neural networks (artificial synapse)
2001 Internship (4 month), University of Natal, Pietermaritzburg, South Africa (Prof. Clive Dennison; Dr. Edith Elliott), Project: Studying a high molecular weight form of the tissue inhibitor for matrix metalloproteases 1 (TIMP-1) in neutrophils and macrophages.
1999-2003 MSc in Biochemistry, University of Bielefeld, Department of Single Molecule Biophysics & Applied Nanoscience (Prof. Dario Anselmetti), Thesis: Characterizing the binding of ATP to ExoP from Sinorhizobium meliloti using Fluorescence Correlation Spectroscopy
1997-1999 BSc in Biochemistry, University of Bielefeld, Department of Chemistry

Publications

  • Galilee M, Britan-Rosich E, Griner SL, Uysal S, Baumgärtel V, Lamb DC, Kossiakoff AA, Kotler M, Stroud RM, Marx A, Alian A.
    The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
    Structure 24(11) 1936-1946. 2016. [doi link]
  • Hendrix J, Baumgärtel V, Schrimpf W, Ivanchenko S, Digman MA, Gratton E, Kräusslich HG, Müller B, Lamb DC.
    Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers.
    J. Cell Biol. 210(4) 629-646. 2015. [doi link]
  • Prescher J, Baumgärtel V, Ivanchenko S, Torrano AA, Bräuchle C, Müller B, Lamb DC.
    Super-Resolution Imaging of ESCRT-Proteins at HIV-1 Assembly Sites.
    PloS Pathog 11(2): e1004677. 2015. [doi link]
  • Baumgärtel V, Müller B, Lamb DC.
    Quantitative Live-Cell Imaging of Human Immunodeficiency Virus (HIV-1) Assembly.
    Viruses 4, 777-799. 2012. [doi link]
  • Baumgärtel V, Ivanchenko S, Müller B, Lamb DC.
    Investigating the Life Cycle of HIV with Fluorescent Proteins.
    in "Springer Series on Fluorescence Methods and Applications", Eds: Wolfbeis O.S., Hof M.; Springer Verlag, Berlin Heidelberg. 2011.
  • Kahms M, Hüve J, Wesselmann R, Farr JC, Baumgärtel V, Peters R.
    Lighting up the nuclear pore complex.
    Eur.J Cell Biol. 90(9), 751-758. 2011. [doi link]
  • Baumgärtel V, Ivanchenko S, Dupont A, Sergeev M, Wiseman PW, Kräusslich H- G, Bräuchle C, Müller B, Lamb DC Dynamics of HIV budding site interactions with an ESCRT component visualized in live cells.
    Nat Cell Biol. 13(4), 469-474. 2011. [doi link]
  • Bradatsch B, Katahira J, Kowalinski E, Bange G, Yao W, Sekimoto T, Baumgärtel V, Boese G, Bassler J, Wild K, Peters R, Yoneda Y, Sinning I, Hurt E
    Arx1 Functions as an Unorthodox Nuclear Export Receptor for the 60S Preribosomal Subunit.
    Molecular Cell 27(5), 767-779. 2007. [doi link]

Awards and Stipends

2011 Römer Award as Postdoc, Ludwig-Maximilians-University, Munich
2011 CeNS Publication Award, Center for Nanoscience (CeNS), Munich
2010 Travel Award, American Society for Biochemistry & Molecular Biology (ASBMB)
2007-2008 PhD Scholarship, Westfälische Wilhelms-University, Muenster

Contact

Room: E2.007
Tel.: +49 (0) 89 2180-77571
E-Mail: Viola.Baumgaertel"at"cup.uni-muenchen.de


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