Laprell, L.; Tochitsky, I.; Kaur, K.; Manookin, M. B.; Stein, M.; Barber, D. M.; Schoen, C.; Michalakis, S.; Biel, Kramer R. H.: Sumser, M.; Trauner, D.; * Van Gelder, R. N. * Photopharmacological Control of Bipolar Cells Enables the Restoration of Visual Function. J. Clin. Invest., (2017). [DOI]


Cheng. B.; Shchepakin, B.; Kavanaugh, M.;* Trauner, D.* A Photoswitchable Inhibitor of a Glutamate Transporter. ACS Chem Neurosci., (2017). [DOI]


Pernpeintner, C.; Frank, J. A.; Urban, P.; Roeske, C. R.; Pritzl, S. D.; Trauner, D.*; Lohmüller, T.* Light-Controlled Membrane Mechanics and Shape Transitions of Photoswitchable Lipid Vesicles. Langmuir 33, 4083-4089 (2017). [DOI]


Podewin, T.; Broichhagen, J.; Frost, C.; Groneberg, D.; Ast, J.; Meyer-Berg, H.; Fine, N. H. F.; Friebe, A.; Zacharias, M.; Hodson, D. J.; Trauner, D.;* Hoffmann-Röder, A.* Optical Control of a Receptor-linked Guanylyl Cyclase Using a Photoswitchable Peptidic Hormone. Chem. Sci. 8, 4644-4653 (2017). [DOI]


Levitz, J.; Broichhagen, J.; Leippe, P.; Konrad, D.; Trauner D: Isacoff, E. Y. Dual Optical Control and Mechanistic Insights Into Photoswitchable Group II and III Metabotropic Glutamate Receptors. Proc. Natl. Acad. Sci. USA 114, E3546–E3554 (2017). [DOI]


Ketels, M.; Konrad, D.; Karaghiosoff, K.; Trauner, D;* Knochel, P.* Selective Lithiation, Magnesiation and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow. Org. Lett. 19, 1666–1669 (2017). [DOI]


Mehta, Z. B.; Johnston, N. R.; Nguyen-Tu, M.-S.; Broichhagen, J.; Schultz, P.; Larner, D. P.; Leclerc, I.; Trauner, D;* Rutter, G. A.;* Hodson, D. J.* Remote Control of Glucose Homeostasis in vivo Using Photopharmacology. Sci. Rep. 7, 291 (2017). [DOI]


Hao, H.; Trauner. D. Furans as Versatile Synthons: Total Syntheses of Caribenol A and Caribenol B. J. Am. Chem. Soc. 139, 12981-12986 (2017). [DOI]


Matsuura, B. S.; Kölle, P.; de Vivie-Riedle, R.*; Trauner, D.*; Meier, R.* Unravelling Photochemical Relationships Amongst Natural Products from Aplysia dactylomela. ACS Central Sci. 3, 39–46 (2017). [DOI]

Open Access


Hartrampf, F.; Furukawa, T.; Trauner, D. A Conia-Ene-Type Cyclization Under Basic Conditions Enables an Efficient Synthesis of (−)-Lycoposerramine R. Angew. Chem. Int. Ed. 56, 893–896 (2017). [DOI]


Volpin, G; Veprek, N. A.; Bellan, A. B.; Trauner, D. Enantioselective Synthesis and Racemization of (–)-Sinoracutine. Angew. Chem. Int. Ed. 56, 897–901 (2017). [DOI]


Trads, J. B.; Burgstaller, J.; Laprell, L.; Konrad, D. B.; de la Osa de la Rosa, L.; Weaver, C. D.; Trauner. D.*; Barber, D.* Optical Control of GIRK Channels Using Visible Light. Org. Biomol. Chem. 15, 76–81 (2017). [DOI]


Frank, J. A.; Franquelim, H. A.; Schwille, P.*; Trauner. D.* Optical Control of Lipid Rafts with Photoswitchable Ceramides. J. Am. Chem. Soc. 138, 12981–12986 (2016). [DOI]


Barber, D. M.; Liu, S.-A.; Gottschling, K.; Sumser, M.; Hollmann, M.; Trauner, D. Optical Control of AMPA Receptors Using a Photoswitchable Quinoxaline-2,3-dione Antagonist. Chem. Sci. 8, 611–615 (2017). [DOI]

Open Access


Johnston, N. R.; Mitchell, R. K.; Haythorne, E.; Paiva Pessoa, M.; Semplici, F.; Ferrer, J.; Piemonti, L.; Marchetti, P.; Bugliani, M.; Bosco, D.; Berishvili, E.; Duncanson, P.; Watkinson, M.; Broichhagen, J.; Trauner, D.; Rutter, G. A.; Hodson, D. J. Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose. Cell Metabolism 24, 389–401 (2016). [DOI]

Open Access


Frank, J. A.; Yushchenko, D.; Hodson, D. A.; Lipstein, N.; Nagpal, J.; Rutter, G. A.; Rhee, J.-S.; Gottschalk, A.; Brose, N.; Schultz, C.; Trauner. D. Photoswitchable Diacylglycerols Enable Optical Control of Protein Kinase C. Nature Chem. Biol. 12, 755–762 (2016). [DOI]


Meier, R., Trauner, D A Synthesis of (±)-Aplydactone. Angew. Chem. Int. Ed. 55, 11251–11255 (2016). [DOI]

Highlighted in Synfacts


Damijonaitis, A.; Barber, D. M.; Trauner, D. The Photopharmacology of Nicotinic Acetylcholine Receptors. Neurotransmitter 3, 1292 (2016). [DOI]


Berlin, S.; Szobota, S.; Reiner, A.; Kienzler, M. A.; Guyon, A.; Trauner. D.; Isacoff. E. Y. A Family of Photoswitchable NMDA Receptors. eLife 5, e12040 (2016). [DOI]

Open Access


Konrad, D.; Frank, J. A.; Trauner, D. Synthesis of Red-shifted Azobenzene Photoswitches via Late-Stage Functionalization. Chem. Eur. J. 22, 4364–4368 (2016). [DOI]


Broichhagen, J.; Klingl, Y.E.; Trauner, D.; Mayer, P. 6-[6-(Pyridin-2-yl)-1,2,4,5-tetrazin-3-yl]pyridin-3-amine monohydrate. Acta Cryst. E72, 238-240 (2016). [DOI]

Open Access


Barber, D.; Schönberger, M.; Burgstaller, J.; Levitz, J.; Weaver, C. D.; Isacoff, E. Y.; Baier, H.; Trauner. D. Optical Control of Neuronal Activity Using a Light Operated GIRK-Channel Opener (LOGO). Chem. Sci. 7, 2347-2352 (2016). [DOI]

Open Access


Williams, B. M.; Trauner, D. Expedient Synthesis of Lycopalhine A. Angew. Chem. Int. Ed. 55, 2191–2194 (2016). [DOI]

Highlighted in Synfacts


Hager, A.; Vrielink, N.; Hager, D.; Lefranc, J.; Trauner, D. Synthetic Approaches towards Alkaloids Bearing α-Tertiary Amines. Nat. Prod. Rep. 33, 491–522 (2016). [DOI]


Simon, S.; Schell,U.; Heuer, N.; Hager, D.; Albers, M. F.; Matthias, J.; Fahrnbauer, F.; Trauner, D.; Eichinger, L.; Hedberg, C.; Hilbi, H. Inter-Kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway. PLOS Pathogens 11, e1005307 (2015). [DOI]


Laprell, L.; Hüll, K.; Stawski, P.; Schön, C.; Michalakis, S.; Biel, M.; Sumser, M. P.; Trauner, D. Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist. ACS Chem. Neurosci. 7, 15–20 (2015). [DOI]

Highlighted as Front Cover


Broichhagen, J.; Podewin T.; Meyer-Berg, H.; von Ohlen, Y.; Johnston, N. R.; Jones, B. J.; Bloom, S. R.; Rutter, G. A.; Hoffmann-Röder, A.*; Hodson, D. J.*; Trauner. D.* Optical Control of Insulin Secretion Using an Incretin Switch. Angew. Chem. Int. Ed. 54, 15565–15569 (2015). [DOI]


Cheng, B.; Trauner D. A Highly Convergent and Biomimetic Total Synthesis of Portentol. J. Am. Chem. Soc. 137, 13800–13803 (2015). [DOI]


Broichhagen, J.; Damijonaitis, A.; Levitz, J.; Sokol, K. R.; Leippe, P.; Konrad, D.; Isacoff, E. Y.; Trauner, D. Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. ACS Central Sci. 1, 383–393 (2015). [DOI]


Bruun, S.; Stoeppler, D.; Keidel. A.; Kuhlmann, U.; Luck, M.; Diehl, A.; Geiger M.A.; Woodmansee, D.; Trauner, D., Hegemann, P.; Oschkinat H.; Hildebrandt, P. Stehfest K. Light-Dark Adaptation of Channelrhodopsin Involves Photoconversion Between the all-trans and 13-cis Retinal Isomers. Biochemistry 54, 5389-5400 (2015). [DOI]


Ellerbock, P.; Armanino. N.; Ilg. M. K.; Webster, R.; Trauner, D. An Eight-Step Synthesis of Epicolactone Reveals its Biosynthetic Origin. Nat. Chem. 7, 879–882 (2015). [DOI]

Highlighted in Nature Chemistry and Synfacts


Guo, Y.; Wolter, T.; Kubař, T.; Sumser, M.; Trauner, D.; Elstner, M. Molecular Dynamics Investigation of Gluazo, a Photo-Switchable Ligand for the Glutamate Receptor Gluk2. PLoS One 10, e0135399 (2015). [DOI]


Laprell, L.; Repak, E.; Franckevicius, V.; Hartrampf, F.; Terhag, J.; Hollmann. M.; Sumser, M.; Rebola, N., DiGregorio, D.*; Trauner, D.* Optical control of NMDA-receptors with a diffusible photoswitch. Nat. Commun. 6, 8076 (2015). [DOI]

Open Access Article


Trauner D. Richard Willstätter and the 1915 Nobel Prize in Chemistry. Angew. Chem. Int. Ed. 54, 11910–11916 (2015). [DOI]


Runtsch, L. S.; Barber, D. M.; Mayer, P.; Groll, M.; Trauner, D.; Broichhagen, J. Azobenzene-based inhibitors of human carbonic anhydrase II. Beilstein J. Org. Chem. 11, 1129-1135 (2015). [DOI]


Borowiak, M.; Nahaboo, W.; Reynders, M.; Nekolla, K.; Jalinot, P.; Hasserodt, J.; Rehberg, M.; DeLattre, M.; Zahler, S.; Vollmar, A.; Trauner, D.*; Thorn-Seshold, O.* Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death. Cell 162, 403-411 (2015). [DOI]

Highlights in EMBO Journal, Nat Chem Bio, Cell Previews, The Economist


Schneider, L. S.; von Schwarzenberg, K.; Lehr, T.; Ulrich, M.; Kubisch-Dohmen, R.; Liebl, J.; Trauner, D.; Menche, D.; Vollmar, A. M. Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer. Cancer Res. 75, 2863-2874 (2015). [DOI]


Hog,D. T.; Huber, F. M. E.; Jiménez-Osés, G.*; Mayer, P.; Houk, K .N., Trauner, D.* Evolution of a Unified Strategy for Complex Sesterterpenoids: Progress toward Astellatol and Total Synthesis of (−)-Nitidasin. Chem. Eur. J. 21, 13646–13665 (2015). [DOI]


Broichhagen, J.; Frank, J.A.; Trauner, D. A Roadmap to Success in Photopharmacology. Acc. Chem. Res. 48, 1947–1960 (2015). [DOI]


Broichhagen, J.; Woodmansee, D. H.; Trauner, D.; Mayer, P. Crystal structure of (E)-1,2-bis­(4-bromo-2,6-di­fluoro­phen­yl)diazene. Acta Crystallogr. Sect. E 71, o459-o460 (2015). [DOI]


Frank, J. A.; Moroni, M.; Moshourab, R.; Sumser, M.; Lewin, G. R.; Trauner, D. Photoswitchable Fatty Acids Enable Optical Control of TRPV1. Nat. Commun. 6, 7188 (2015). [DOI]

Open Access Article; Chemistry and Biology Select


Trauner, D. Molecular Aesthetics. Edited by Peter Weibel and Ljiljana Fruk (Book Review). Angew. Chem. Int. Ed. 54, 6970 (2015). [DOI]


Strych, S.; Journot, G.; Pemberton, R. P.; Wang , S. C.; Tantillo, D.*; Trauner, D.* Biomimetic Total Synthesis of Santalin Y. Angew. Chem. Int. Ed. 54, 5079–5083 (2015). [DOI]

Highlighted as Front Cover, Highlighted in Synfacts


Damijonaitis, A.; Broichhagen, J.; Urushima, T.; Hüll, K.; Nagpal, J.; Laprell, L.; Schönberger, M.; Woodmansee, David; Rafiq, A.; Sumser, M.; Kummer, W.; Gottschalk, A.; Trauner, D. AzoCholine Enables Optical Control of Alpha 7 Nicotinic Acetylcholine Receptors in Neural Networks. ACS Chem. Neurosci. 6, 701–707 (2015). [DOI]


Broichhagen, J.; Frank, J. A.; Johnston, N. R.; Mitchell, K.; Smid, K.; Marchetti, P.; Bugliani, M.; Rutter, G. A.; Trauner. D.*; Hodson, D.* A Red-Shifted Photochromic Sulfonylurea for the Remote Control of Pancreatic Beta Cell Function. Chem. Commun. 51, 6018-6021 (2015). [DOI]


Maryasin, B.; Olbrich, M.; Trauner, D.*; Ochsenfeld, C.* Calculated Nuclear Magnetic Resonance Spectra of Polytwistane and Related Hydrocarbon Nanorods. J. Chem. Theory Comput. 11, 1020–1026 (2015). [DOI]


Olbrich, M.; Mayer, P.; Trauner, D. Synthetic Studies Toward Polytwistane Hydrocarbon Nanorods. J. Org. Chem. 80, 2042–2055 (2014). [DOI]

Highlighted as Front Cover


Rullo, A.; Reiner, A.; Reiter, A.; Trauner, D.; Isacoff, E.; Woolley, A. Long Wavelength Optical Control of Glutamate Receptor Ion Channels Using a Tetra-Ortho-Substituted Azobenzene Derivative. Chem. Commun. 50, 14613–14615 (2014). [DOI]


Calik, M.; Auras, F.; Salonen, L.; Bader, K.; Gill, I.; Handloser, M.; Medina, D.; Dogru, M.; Löbermann, L. M.; Trauner, D.; Hartschuh, A.; Bein, T. Extraction of Photogenerated Electrons and Holes From a COF Integrated Heterojunction. J. Am. Chem. Soc. 136, 17802–17807 (2014). [DOI]


AzimiHashemi, N.; Erbguth, K.; Vogt, A.; Riemensperger, T.; Rauch, E.; Woodmansee, D.; Nagpal, J.; Brauner, M.; Sheves, M.; Fiala, A.; Kattner, L.; Trauner, D.; Hegemann, P.; Gottschalk, A.; Liewald, J. F. Synthetic Retinal Analogues Modify the Spectral and Kinetic Characteristics of Microbial Rhodopsin Optogenetic Tools. Nat. Commun. 5, 5810 (2014). [DOI]


Stichnoth, D.; Kölle, P.; Kimbrough, T. J.; Riedle, E.; de Vivie-Riedle, R.*; Trauner, D.* Photochemical Formation of Intricarene. Nat. Commun. 6, 5597 (2014). [DOI]


Ellerbrock, P.; Armanino, N.; Trauner, D. Biomimetic Synthesis of the Calcineurin Phosphatase Inhibitor Dibefurin. Angew. Chem. Int. Ed. 53, 13414–13418 (2014). [DOI]


Broichhagen, J.; Schönberger, M.; Cork, S.; Frank, J.; Marchetti, P.; Bugliani, M.; Shapiro, A. M. J.; Trapp, S.; Rutter, G.; Hodson, D. J.; Trauner, D. Optical Control of Insulin Release. Nat. Commun. 5, 5116 (2014). [DOI]


Auras, F.; Li, Y.; Löbermann, F.; Döblinger, M.; Schuster, J.; Peter, L. M.; Trauner, D.; Bein, T. A Zinc Phthalocyanine-Based Periodic Mesoporous Organosilica Exhibiting Charge Transfer to Fullerenes. Chem. Eur. J. 20, 14971–14975 (2014). [DOI]


Broichhagen, J.; Trauner, D. The In Vivo Chemistry of Photoswitched Tethered Ligands. Curr. Opin. Chem. Biol. 21, 121-127 (2014). [DOI]


Myers. E.; Herrero-Gómez, E.; Baitinger, I.; Lachs, J.; Mayer, P.; Hanni, M.; Ochsenfeld, C.; Trauner, D. Total Synthesis of the Proposed Structure of Trichodermatide A. J. Org. Chem. 79, 9812–9817 (2014). [DOI]

Highlighted in Synfacts


Carta, V.; Pangerl, M.; Baur, R.; Puthenkalam, R.; Ernst, M.; Trauner, D.; Sigel E. A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels. PLoS ONE 9, e106688 (2014). [DOI]


Middendorp, S.J.; Hurni, E.; Schönberger, M.; Stein, M.; Pangerl, M.; Trauner, D.; Sigel, E. Relative Positioning of Classical Benzodiazepines to the γ2‑Subunit of GABA-A Receptors. ACS Chem. Biol. 9, 1846–1853 (2014). [DOI]


Schönberger, M.; Althaus, M., Fronius, M.; Clauss, W., Trauner, D. Controlling Epithelial Sodium Channels With Light Using a Photoswitchable Amiloride. Nat. Chem. 6, 712–719 (2014). [DOI]


Hog, D.; Huber. F.; Mayer, P.; Trauner, D. The Total Synthesis of (–)-Nitidasin. Angew. Chem. Int. Ed. 53, 8513–8517 (2014). [DOI]

Highlighted in Synfacts


Trauner, D. Der Schattensammler. Die allerletzte Autobiografie. By Carl Djerassi. (Book Review). Angew. Chem. Int. Ed. 53, 2808 (2014). [DOI]


Schönberger, M.; Damijonaitis, A.; Zhang, Z.; Nagel, D.; Trauner, D. Development of a New Photochromic Ion Channel Blocker via Azologization of Fomocaine. ACS Chem. Neurosci. 5, 514–518 (2014). [DOI]


Guimond, G.; Mayer, P.; Trauner, D. Development of an Iron(II)-Catalysed Aerobic Catechol Cleavage and Biomimetic Synthesis of Betanidin. Chem. Eur. J. 20, 9519–9523 (2014). [DOI]


Broichhagen, J.; Jurastow, I.; Iwan, K.; Kummer, W.; Trauner, D. Optical Control of Acetylcholinesterase with a Tacrine Switch. Angew. Chem. Int. Ed. 53, 7657–7660 (2014). [DOI]


Meier, R.; Strych, S.; Trauner, D. Biomimetic Synthesis of (±)-Merochlorin B. Org. Lett. 16, 2634–2637 (2014). [DOI]


Wolter, T.; Steinbrecher, T.; Trauner, D.; Elstner, M. Ligand Photo-Isomerization Triggers Conformational Changes in iGluR2 Ligand Binding Domain. PLOS One 9, e97216 (2014). [DOI]


Trauner, D. Finding Function and Form (Editorial). Nat. Prod. Rep. 31, 411–413 (2014). [DOI]


Pangerl, M.; Höhlein, I.; Trauner, D. A Robust Route towards Functionalized Pyrrolizidines as Precursors for Daphniphyllum Alkaloids. Synlett 25, 741–745 (2014). [DOI]


Tochitsky, I.; Polosukhina, A.; Degtyar, V. E.; Gallerani, N.; Smith, C. M.; Friedman, A.; Van Gelder, R. N.; Trauner, D.; Kaufer, D.; Kramer R. H. Restoring Visual Function in Blind Mice With a Photoswitch That Exploits Electrophysiological Remodeling of Retinal Ganglion Cells. Neuron 81, 800–813 (2014). [DOI]


Schönberger, M.; Trauner, D. Optical Control of μ-Opioid Receptors. Angew. Chem. Int. Ed. 53, 3264–3267 (2014). [DOI]


Barua, S. R.; Quanz, H.; Olbrich, M.; Schreiner, P. R.; Trauner, D.; Allen, W. D. Polytwistane. Chem. Eur. J. 20, 1638–1645 (2014). [DOI]


Olbrich, M.; Mayer, P.; Trauner, D. A Step Toward Polytwistane: Synthesis and Characterization of C2-Symmetric Tritwistane. Org. Biomol. Chem. 12, 108–112 (2014). [DOI]

Highlighted in Synfacts


Hager, A.; Kuttruff, C. A.; Herrero-Gomez, E.; Trauner, D. Toward the Total Synthesis of Ansalactam A. Tetrahedron Lett. 55, 59–62 (2014). [DOI]


Chen, I. T.; Baitinger, I.; Schreyer, L.; Trauner, D. Total Synthesis of Sandresolide B and Amphilectolide. Org. Lett. 16, 166–169 (2014). [DOI]


Reiter, A.; Skerra, A., Trauner, D.*; Schiefner, A. A Photoswitchable Neurotransmitter Analogue Bound to its Receptor. Biochemistry 52, 8972–8974 (2013). [DOI]


Broichhagen, J.; Trauner, D. Bilirubin in a New Light. Angew. Chem. Int. Ed. 52, 13868–13870 (2013). [DOI]


Isacoff, E.; Kramer, R.; Trauner, D. Challenges and Opportunities in Optochemical Genetics in Optogenetics (Hegemann, P., Sigrist, S. eds., De Gruyter, 2013, 35-46).


Kienzler, M. A.; Reiner, A.; Trautman, E.; Yoo, S.; Trauner, D.*; Isacoff, E. Y.* A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Visible Light Control of an Ionotropic Glutamate Receptor. J. Am. Chem. Soc. 135, 17683–17686 (2013). [DOI]


Li, Y.; Auras, F.; Loebermann, F.; Döblinger, M.; Schuster, J.; Peter, L. M.; Trauner, D.*; Bein, T.* A Photoactive Porphyrin-Based Periodic Mesoporous Organosilica Thin Film. J. Am. Chem. Soc. 135, 18513–18519 (2013). [DOI]


Hager, D.; Paulitz, C.; Tiebes, J.; Mayer, P.; Trauner, D. Total Synthesis of Herbicidin C and Aureonuclemycin: Impasses and New Avenues. J. Org. Chem. 78, 10784–10801 (2013). [DOI]


Hornig, S.; Ohmert, I.; Trauner, D.; Ader, C.; Baldus, M.; Pongs, O. Tetraphenylporphyrin Derivative Specifically Blocks Members of the Voltage-Gated Potassium Channel Subfamily Kv1. Channels 7, 473–482 (2013). [DOI]


Hager, A.; Kuttruff, C. A.; Hager, D.; Terwilliger, D. W.; Trauner, D. Toward the Total Synthesis of Divergolides C and D. Synlett 24, 1915–1920 (2013). [DOI]


Löbermann, F.; Weisheit, L.; Trauner, D. Intramolecular Vinyl Quinone Diels-Alder Reactions: Asymmetric Entry to the Cordiachrome Core and Synthesis of (–)-Isoglaziovianol. Org. Lett. 15, 4324–4326 (2013). [DOI]


Strych, S.; Trauner, D. Biomimetic Synthesis of Santalin A,B and Santarubin A,B, the Major Colorants of Red Sandalwood. Angew. Chem. Int. Ed. 52, 9509–9512 (2013). [DOI]

Synform: [DOI]


Stein, M.; Breit, A.; Fehrentz, T.; Gudermann, T.; Trauner, D. Optical Control of TRPV1 Channels. Angew. Chem. Int. Ed. 52, 9845–9848 (2013). [DOI]


Webster, R.; Gaspar, B.; Mayer, P.; Trauner, D. Studies toward the Biomimetic Total Synthesis of (–)-PF-1018. Org. Lett. 15, 1866–1869 (2013). [DOI]


Levitz, J.; Pantoja, C.; Gaub, B; Janovjak, H.; Reiner, A.; Hoagland, A.; Schoppik, D.; Kane, B.; Stawski, P.; Schier, A. F.; Trauner, D.*; Isacoff, E. Y.* Optical Control of Metabotropic Glutamate Receptors. Nat. Neurosci. 16, 507–516 (2013). [DOI]


Izquierdo, M., Trauner, D., Llobet, A., Gorostiza, P. Optical Control of Calcium-Regulated Exocytosis. Biochim. Biophys. Acta 1830, 2853–2860 (2013). [DOI]


Beaulieu, E. D.; Ionescu, M.; Chaterjee, S.; Yokota, K.; Trauner, D.; Lindow, S. Characterization of a Diffusible Signaling Factor from Xylella Fastidiosa. mBio 4, (2013). [DOI]


Izquierdo-Serra, M.; Trauner, D.; Lobet, A.; Gorostiza, P. Optical Modulation of Neurotransmission Using Calcium Photocurrents through the Ion Channel LiGluR. Frontiers. Mol. Neurosci. 6, 3 (2013). [DOI]


Banghart, M. R., Trauner, D. A 1H NMR Assay for Measuring the Photostationary States of Photoswitchable Ligands. Methods Mol. Biol. 995, 107–120 (2013). [DOI]


Von Schwarzenberg, K.; Wiedmann, R. M.; Zahler, S.; Trauner, D.; Vollmar, A. M. Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition. J. Biol. Chem. 288, 1385–1396 (2013). [DOI]


Wiedmann, R. M.; von Schwarzenberg, K.; Palamidessi, A.; Schreiner, L.; Kubisch, R.; Liebl, J.; Schempp, C.; Trauner, D.; Vereb, G.; Zahler, S.; Wagner, E. ; Muller, R. ; Scita, G.; Vollmar, A. M. The V-ATPase-Inhibitor Archazolid Abrogates Tumor Metastasis Via Inhibition of Endocytic Activation of the Rho-GTPase Rac1. Cancer Res. 72, 5976–5987 (2012). [DOI]


Seidel, S. A. I.; Wienken, C. J.; Geissler, S.; Jerabek-Willemsen, M.; Duhr, S.; Reiter, A.; Trauner, D.; Braun, D.; Baaske, P. Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein-Ligand Binding. Angew. Chem. Int. Ed. 51, 10656-10659 (2012). [DOI]

CeNS Publication Award 2012. [PDF]


Schröckeneder, A. ; Stichnoth, D.; Mayer, P.; Trauner, D. The Crystal Structure of the Dess–Martin Periodinane. Beilstein J. Org. Chem. 8, 1523–1527 (2012). [DOI]


Trauner, D. Molecular Switches and Cages. Beilstein J. Org. Chem. 8, 870–871 (2012). [DOI]


Stein, M.; Middendorp, S. J.; Carta, V.; Pejo, E.; Raines, D. E.; Forman, S. A.; Sigel, E.; Trauner, D. Azo-Propofols: Photochromic Potentiators of GABAA Receptors. Angew. Chem. Int. Ed. 51, 10500–10504 (2012). [DOI]



Kuttruff, C. A.; Mayer, P.; Trauner, D. Evolution of a Synthetic Strategy for the Variecolortides. Eur. J. Org. Chem. 27, 5151–5161 (2012). [DOI]


Polosukhina, A.; Litt, J.; Tochitsky, I.; Nemargut, J.; Sychev, Y.; De Kouchkovsky, I.; Huang, T.; Borges, K.; Trauner, D.; Van Gelder, R. N.; Kramer R. H. Photochemical Restoration of Visual Responses in Blind Mice. Neuron 75, 271–282 (2012). [DOI]

Highlighted in Nature 488, 8 (2012). Highlighted in C&EN 31, 12 (2012).


Fehrentz, T.; Kuttruff, C. A.; Huber, F. M. E.; Kienzler M. A.; Mayer P.; Trauner, D. Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers. ChemBioChem 13, 1746–1749 (2012). [DOI]


Hog, D. T., Mayer, P., Trauner, D. A Unified Approach to trans-Hydrindane Sesterterpenoids. J. Org. Chem. 77, 5838–5843 (2012). [DOI]


Hog, D. T.; Webster, R.; Trauner, D. Synthetic Approaches toward Sesterterpenoids. Nat. Prod. Rep. 29, 752–779 (2012). [DOI]


Hager, D.; Mayer, P.; Paulitz, C.; Tiebes, J.; Trauner, D. Stereoselective Total Syntheses of Herbicidin C and Aureonuclemycin through Late-Stage Glycosylation. Angew. Chem. Int. Ed. 51, 6525–6528 (2012). [DOI]


Matveenko, M.; Liang, G.; Lauterwasser, E. M. W.; Zubia, E.*; Trauner, D.* A Total Synthesis Prompts the Structure Revision of Haouamine B. J. Am. Chem. Soc. 134, 9291–9295 (2012). [DOI]


Stawski, P.; Sumser, M.; Trauner, D. A Photochromic Agonist of AMPA Receptors. Angew. Chem. Int. Ed. 51, 5748–5751 (2012). [DOI]


Mourot, A.; Fehrentz, T.; Bautista, D.; Trauner, D.*; Kramer, R.* Rapid Optical Control of Nociception with an Ion-Channel Photoswitch. Nature Methods 9, 396–402 (2012). [DOI]


Kuttruff, C. A.; Geiger, S.; Cakmak, M.; Mayer, P.; Trauner, D. An Approach to Aminonaphthoquinone Ansamycins Using a Modified Danishefsky Diene. Org. Lett. 14, 1070–1073 (2012). [DOI]


Sofiyev, V.; Lumb, J.-P. ; Volgraf, M.; Trauner, D. Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry. Chem. Eur. J. 18, 4999–5005 (2012). [DOI]


Tochitsky, I.; Banghart M. R.; Mourot, A.; Zhao, J.Z.; Gaub, B.; Kramer, R.; Trauner, D. Optochemical Control of Genetically Engineered Neuronal Nicotinic Acetylcholine Receptors. Nature Chemistry 4, 105–111 (2012). [DOI]


Fehrentz, T.; Schönberger, M.; Trauner, D. Optochemical Genetics. Angew. Chem. Int. Ed. 50, 12156–12182 (2011). [DOI]


Caporale, N.; Kolstad, K. D.; Lee, T.; Tochitsky, I.; Dalkara, D.; Trauner, D.; Kramer, R.; Dan, Y.; Isacoff E. Y.; Flannery, J. G. LiGluR Restores Visual Responses in Rodent Models of Inherited Blindness. Molecular Therapy 19, 1212–1219 (2011). [DOI]


Gaspar B., Trauner, D. Electrocyclic Reactions in Science of Synthesis, Stereoselective Synthesis 3: Stereoselective Pericyclic Reactions, Cross Coupling, C―H and C―X Activation (2011, Thieme: Stuttgart & New York, 383–402).


Volgraf, M., Banghart, M.; Trauner, D. Switchable Proteins and Channels in Molecular Switches (Second Edition, 2011, Vol. 2, Feringa, B. ed., Wiley-VCH: Weinheim, 563–593).


Mourot, A.; Kienzler, M. A.; Banghart, M. R.; Fehrentz, T.; Huber, F. M. E.; Stein, M.; Kramer, R. H.; Trauner, D. Tuning Photochromic Ion Channel Blockers. ACS Chemical Neuroscience 2, 536–543 (2011). [DOI]


Cakmak, M.; Mayer, P.; Trauner, D. An Efficient Synthesis of Loline Alkaloids. Nat. Chem. 3, 543–545 (2011). [DOI]


Doris L. Fortin, D. L.; Dunn, T. W.; Fedorchak, A; Allen, D.; Montpetit, R.; Banghart, M. R.; Trauner, D.; Adelman, J. P.; Kramer, R. H. Optogenetic Photochemical Control of Designer K+ Channels in Mammalian Neurons. J. Neurophys. 106, 488–496 (2011). [DOI]


Hager, A.; Mazunin, D.; Mayer, P.; Trauner, D. Synthetic Studies toward A-74528. Org. Lett. 13, 1386–1389 (2011). [DOI]


Kerschensteiner, L.; Löbermann, F.; Steglich, W.; Trauner, D. Crocipodin, a Benzotropolone Pigment from the Mushroom Leccinum Crocipodium (Boletales). Tetrahedron 67, 1536–1539 (2011). [DOI]


Kuttruff, C. A.; Zipse, H.; Trauner, D. Concise Total Syntheses of Variecolortides A and B through an Unusual Hetero-Diels-Alder Reaction. Angew. Chem. Int. Ed. 50, 1402–1405 (2011). [DOI]


Baitinger, I. ; Mayer, P.; Trauner, D. Toward the Total Synthesis of Maoecrystal V: Establishment of Contiguous Quaternary Stereocenters. Org. Lett. 12, 5656–5659 (2010). [DOI]


Lumb, J.-P.; Krinsky, J.; Trauner, D. Theoretical Investigation of the Rubicordifolin Cascade. Org. Lett. 12, 5162–5165 (2010). [DOI]


Hilf, R. J. C.; Bertozzi, C.; Zimmermann, I.; Reiter, A.; Trauner, D.; Dutzler, R. Structural Basis of Open Channel Block in a Prokaryotic Pentameric Ligand-Gated Ion Channel. Nature Struct. Mol. Biol. 17, 1330–1337 (2010). [DOI]


Stawski P., Janovjak H., Trauner D. Pharmacology of Ionotropic Glutamate Receptors: A Structural Perspective. Bioorg Med Chem. 18, 7759–7772 (2010). [DOI]


Janovjak, H.; Szobota, S.; Wyart, C.; Trauner, D.; Isacoff, E. Y. A Light-Gated, Potassium-Selective Glutamate Receptor for the Optical Inhibition of Neuronal Firing. Nature Neurosci. 13, 1027–1032 (2010). [DOI]


Abrams, Z. R.; Warrier, A.; Trauner, D.; Zhang, X. A Signal Processing Analysis of Purkinje Cells in Vitro. Frontiers in Neural Circuits 4, 1–13 (2010). [DOI]


Löbermann, F.; Mayer, P.; Trauner, D. Biomimetic Synthesis of (–)-Pycnanthuquinone C through the Diels-Alder Reaction of a Vinyl Quinone. Angew. Chem. Int. Ed. 49, 6199–6202 (2010). [DOI]


Pangerl, M.; Chambers C. H.; Trauner, D. Total Synthesis of Newbouldine Via Reductive N-N Bond Formation. Tetrahedron 66, 6626–6631 (2010). [DOI]


Bishop, L. M.; Roberson, R. E.; Bergman, R. G.; Trauner, D. On the Development of Catalytic Carba-6π Electrocyclizations. Synthesis, 2233–2244 (2010). [DOI]


Kimbrough, T. J.; Roethle, P. A.; Mayer, P.; Trauner, D. Total Synthesis of Coralloidolides A, B, C, and E. Angew. Chem. Int. Ed. 49, 2619–2621 (2010). [DOI]


Banghart, M. R.; Mourot, A.; Fortin, D. L.; Yao, J. Z.; Kramer, R. H.; Trauner, D. Photochromic Blockers of Voltage-Gated Potassium Channels. Angew. Chem. Int. Ed. 48, 9097–9101 (2009). [DOI]


Kramer, R. H.; Fortin, D. L.; Trauner, D. New Photochemical Tools for Controlling Neuronal Activity. Curr. Opin. Neurobiol. 19, 544–552 (2009). [DOI]


Wyart C.; Del Bene, F.; Warp, E.; Scott, E. K.; Trauner, D.; Baier, H.; Isacoff E. Y. Optogenetic Dissection of a Behavioural Module in the Vertebrate Spinal Cord. Nature 461, 407–410 (2009). [DOI]


Martos, V.; Bell, S. C.; Santos, E.; Isacoff, E. Y.; Trauner, D., de Mendoza, J. Calix[4]arene-Based Conical-Shaped Ligands for Voltage-Dependent Potassium Channels. PNAS 106, 10482–10486 (2009). [DOI]


Numano, R.; Szobota, S.; Laud, A. Y.; Gorostiza, P.; Volgraf, M.; Roux, B.; Trauner, D.; Isacoff, E. Y. Nanosculpting Reversed Wavelength Sensitivity into a Photoswitchable iGluR. PNAS 106, 6814–6819 (2009). [DOI]


Bowie, A. L. Jr.; Trauner D. Total Synthesis of (±)-Rhazinal Using Novel Palladium-Catalyzed Cyclizations. J. Org. Chem. 74, 1581–1586 (2009). [DOI]


Bishop, L. M.; Barbarow, J. E.; Bergman, R. G.; Trauner, D. Catalysis of 6π Electrocyclizations. Angew. Chem. Int. Ed. 47, 8100–8103 (2008). [DOI]


Lumb, J.-P.; Brastianos, H. C.; Carr, G.; Chung, M. K. W.; Munzel, M.; Mauk, A. G.; Andersen, R. J.; Trauner, D. Biomimetic Synthesis of the IDO Inhibitors Exiguamine A and B. Nature Chem. Bio. 4, 535–537 (2008). [DOI]


Lumb, J.-P.; Choong, K. C.; Trauner, D. Ortho-Quinone Methides from Para-Quinones: Total Synthesis of Rubioncolin B. J. Am. Chem. Soc. 130, 9230–9231 (2008). [DOI]


Kienzler, M. A.; Suseno, S; Trauner, D. Vinyl Quinones as Diels-Alder Dienes: Concise Synthesis of (–)-Halenaquinone. J. Am. Chem. Soc. 130, 8604–8605 (2008). [DOI]


Trauner, D. Introduction: Chemical Approaches to Neurobiology (guest editorial). Chem. Rev. 108, 1499–1500 (2008). [DOI]


Bishop, L. M.; Houk, K. N.; Winkler, M.; Bergman, R. G.; Trauner, D. Mechanistic Investigations of the Acid-Catalyzed Cyclization of a Vinyl Ortho-Quinone Methide. Chem. Eur. J. 14, 5405–5408 (2008). [DOI]


Ader, C.; Schneider, R.; Hornig, S.; Velisetty, P.; Wilson; E. M.; Lange, A.; Giller, K.; Ohmert, I.; Martin-Eauclaire, M.-F.; Trauner, D.; Becker, S.; Pongs, O.; Baldus, M. A Structural Link between Inactivation and Block of a K+ Channel. Nature Struct. Mol. Biol. 15, 605–612 (2008). [DOI]


Roethle, P. A.; Trauner D. The Chemistry of Marine Furanocembranoids, Pseudopteranes, Gersolanes, and Related Natural Products. Nat. Prod. Rep. 25, 298–317 (2008). [DOI]


Fortin, D. L.; Banghart, M. R., Dunn, T. D.; Borges, K.; Wagnaar, D. A.; Gaudry, Q.; Karakossian, M.; Otis, T. W.; Kristan, W. B.; Trauner, D.: Kramer, R. H. Photochemical Control of Endogenous Ion Channels and Cellular Excitability. Nature Meth. 5, 331–338 (2008). [DOI]


Beaulieu, E. D.; Voss, L.; Trauner, D. Conjugate Addition of Allyl Stannanes with Concomitant Triflation. Org. Lett. 10, 869–872 (2008). [DOI]


Sofiyev, V.; Navarro, G.; Trauner, D. Biomimetic Synthesis of the Shimalactones. Org. Lett. 10, 149–152 (2008). [DOI]


Harvey, J.; Trauner, D. Regulating Enzymatic Activity with a Photoswitchable Affinity Label. Chem. Biochem. 9, 191–193 (2008). [DOI]


Trauner, D. Enolates in Science of Synthesis, Houben-Weyl, Methods of Molecular Transformations (Volume 32, pp. 547–588, Stuttgart, New York: Thieme 2008).


Trauner, D. Enols in Science of Synthesis, Houben-Weyl, Methods of Molecular Transformations (Volume 32, pp. 533–545, Stuttgart, New York: Thieme 2008).


Wang, S.; Szobota, S.; Wang, Y.; Volgraf, M.; Liu, Z.; Sun, C.; Trauner, D.; Isacoff, E. Y.; Zhang, X. All Optical Interface for Parallel, Remote, and Spatiotemporal Control of Neuronal Activity. Nano Lett. 7, 3859–3863 (2007). [DOI]


Comstock, M. J.; Levy, N.; Kirakosian, A.; Cho, J.; Lauterwasser, F.; Harvey, J. H.; Strubbe, D. A.; Fréchet, J. M. J.; Trauner, D.; Louie, S. G.; Crommie, M. F. Reversible Photomechanical Switching of Individual Engineered Molecules at a Metallic Surface. Phys. Rev. Lett. 99, 038301 (2007). [DOI]


Roethle, P. A.; Chen, I. T.; Trauner, D. Total Synthesis of (–)-Archazolid B. J. Am. Chem. Soc. 129, 8960–8961 (2007). [DOI]


Gorostiza, P.; Volgraf, M.; Numano,R.; Szobota, S.; Trauner, D.; Isacoff, E. Y. Mechanisms of Photoswitch Conjugation and Light Activation of an Ionotropic Glutamate Receptor. Proc. Natl. Acad. Sci. 104, 10865–10870 (2007). [DOI]


Rosa, C.P.; Kienzler, M.; Olson, B.S.; Liang, G.; Trauner, D. Total Synthesis of Smenochromene B through Ring Contraction. Tetrahedron 63, 6529–6534 (2007). [DOI]


Szobota, S.; Gorostiza, P.; Del Bene, F.; Wyart, C.; Fortin, D. L.; Kolstad, K. D.; Tulyathan, O.; Volgraf, M.; Numano, R.; Aaron, H. L.; Scott, E. K.; Kramer, R. H.; Flannery, J.; Baier, H.; Trauner, D.; Isacoff, E. Remote Control of Neuronal Activity with a Light-Gated Glutamate Receptor. Neuron 54, 535–545 (2007). [DOI]


Harvey, J. H.; Bulter, B. K.; Trauner, D. Functionalized Azobenzenes through Cross-Coupling with Organotrifluoroborates. Tetrahedron Lett. 48, 1661–1664 (2007). [DOI]


Wilson, E. M.; Trauner, D. Concise Synthesis of the Bacterial DNA Primase Inhibitor (+)-Sch 642305. Org. Lett. 9, 1327–1329 (2007). [DOI]


Volgraf, M.; Gorostiza, P.; Szobota,S.; Helix, M. R.; Isacoff, E. Y.; Trauner, D. Reversibly Caged Glutamate: A Photochromic Agonist of Ionotropic Glutamate Receptors. J. Am. Chem. Soc. 129, 260–261 (2007). [DOI]


Gradl, S. N.; Trauner, D. The Meirwein-Eschenmoser-Claisen Rearrangement in Claisen Rearrangements (Hiersemann, M.; Nubbemeyer, U., Eds; Weinheim: Wiley-VCH 2005, Chapter 7).


Miller, A. K.; Hughes, C. C.; Kennedy-Smith, J. J.; Gradl, S. N.; Trauner, D. Total Synthesis of (–)-Heptemerone B and (–)-Guanacastepene E. J. Am. Chem. Soc. 128, 17057–17062 (2006). [DOI]


Banghart, M. R.; Volgraf, M.; Trauner, D. Engineering Light-Gated Ion Channels. Biochemistry 45, 15129–15141 (2006). [DOI]


Roethle, P. A.; Hernandez, P. T.; Trauner, D. Exploring Biosynthetic Relationships among Furanocembranoids: Synthesis of (–)-Bipinnatin J, (+)-Intricarene, (+)-Rubifolide, and (+)-Isoepilophodione B. Org. Lett. 8, 5901–5904 (2006). [DOI]


Grundl, M. A.; Kaster, A.; Beaulieu, E. D.; Trauner, D. Development of a Friedel-Crafts Triflation. Org. Lett. 8, 5429–5432 (2006). [DOI]


Müller, M.; Kusebauch, B.; Liang, G.; Beaudry, C. M.; Trauner, D.; Hertweck, C. Photochemical Origin of the Immunosuppressive SNF4435C/D and Formation of Orinocin through "Polyene Splicing". Angew. Chem. Int. Ed. 45, 7835–7838 (2006). [DOI]


Miller, A.K.; Trauner, D. Mapping the Chemistry of Highly Unsaturated Pyrone Polyketides. Synlett 14, 2295–2316 (2006). [DOI]


Chambers, J. J.; Banghart, M. R.; Trauner, D.; Kramer, R. H. Light-Induced Depolarization of Neurons Using a Modified Shaker K+ Channel and a Molecular Photoswitch. J. Neurophysiol. 96, 2792–2796 (2006). [DOI]


Liang, G.; Xu, Y.; Seiple, I. B.; Trauner, D. Synthesis of Taiwaniaquinoids Via Nazarov Triflation. J. Am. Chem. Soc. 128, 11022–11023 (2006). [DOI]


Roethle, P. A.; Trauner, D. Expedient Synthesis of (±)-Bipinnatin J. Org. Lett. 8, 345–347 (2006). [DOI]


Grundl, M. A.; Trauner, D. Synthetic Studies toward the Haouamines. Org. Lett. 8, 23–25 (2006). [DOI]


Volgraf, M.; Gorostiza, P.; Numano, R.; Kramer, R. H.; Isacoff, E. Y.; Trauner, D. Allosteric Control of an Ionotropic Glutamate Receptor with an Optical Switch. Nature Chem. Bio. 2, 47–52 (2006). [DOI]

Featured in Science: [DOI]


Lumb, J. P.; Trauner, D. Pericyclic Reactions of Prenylated Naphthoquinones: Biomimetic Syntheses of Mollugin and Microphyllaquinone. Org. Lett. 7, 5865–5868 (2005). [DOI]


Kramer, R. H.; Chambers, J. J.; Trauner, D. Photochemical Tools for Remote Control of Ion Channels in Excitable Cells. Nature Chem. Bio. 1, 360–365 (2005). [DOI]


Beaudry, C. M.; Malerich, J. P.; Trauner, D. Biosynthetic and Biomimetic Electrocyclizations. Chem. Rev. 105, 4757–4778 (2005). [DOI]


Bowie, A. L., Jr.; Hughes, C. C.; Trauner, D. Concise Synthesis of (±)-Rhazinilam through Direct Coupling. Org. Lett. 7, 5207–5209 (2005). [DOI]


Zuidema, D. R.; Miller, A. K.; Trauner, D.; Jones, P. B. Photosensitized Conversion of 9,10-Deoxytridachione to Photodeoxytridachione. Org. Lett. 7, 4959–4962 (2005). [DOI]


Beaudry, C. M.; Trauner, D. Total Synthesis of (–)-SNF4435 C and (+)-SNF4435 D. Org. Lett. 7, 4475–4477 (2005). [DOI]


Trauner, D. A Glimpse at the Grail. Nature Chem. Bio. 1, 189–191 (2005). [DOI]


Endicott, C. A.; Strauss, H. L.; Hughes, C. C.; Trauner, D. Infrared Hole Burning and Conformational Change in a Borane-Ammonia Complex. J. Phys Chem. A 109, 7714–7717 (2005). [DOI]


Hughes, C. C.; Miller, A. K.; Trauner, D. An Electrochemical Approach to the Guanacastepenes. Org. Lett. 7, 3425–3428 (2005). [DOI]


Miller, A. K.; Trauner, D. Mining the Tetraene Manifold: Total Synthesis of Complex Pyrones from Placobranchus ocellatus. Angew. Chem., Int. Ed. 44, 4602–4606 (2005). [DOI]


Barbarow, J. E.; Miller, A. K.; Trauner, D. Biomimetic Synthesis of Elysiapyrones A and B. Org. Lett. 7, 2901–2903 (2005). [DOI]


Liang, G. X.; Seiple, I. B.; Trauner, D. Stereoselective Syntheses of the Bioactive Polypropionates Aureothin, N-Acetylaureothamine, and Aureonitrile. Org. Lett. 7, 2837–2839 (2005). [DOI]


Grundl, M. A.; Kennedy-Smith, J. J.; Trauner, D. Rational Design of a Chiral Palladium(0) Olefin Complex of Unprecedented Stability. Organometallics 24, 2831–2833 (2005). [DOI]


Malerich, J. P.; Maimone, T. J.; Elliott, G. I.; Trauner, D. Biomimetic Synthesis of Antimalarial Naphthoquinones. J. Am. Chem. Soc. 127, 6276–6283 (2005). [DOI]

Correction: [DOI]


Khuong, K. S.; Beaudry, C.; Trauner, D.; Houk, K. N. Dienophile Twisting and Substituent Effects Influence Reaction Rates of Intramolecular Diels-Alder Cycloadditions: A DFT Study. J. Am. Chem. Soc. 127, 3688–3689 (2005). [DOI]


Lumb, J. P.; Trauner, D. Biomimetic Synthesis and Structure Elucidation of Rubicordifolin, a Cytotoxic Natural Product from Rubia Cordifolia. J. Am. Chem. Soc. 127, 2870–2871 (2005). [DOI]


Liang, G. X.; Miller, A. K.; Trauner, D. Stereoselective Synthesis of Cyercene A and the Placidenes. Org. Lett. 7, 819–821 (2005). [DOI]


Olson, B. S.; Trauner, D. Concise Synthesis of (±)-Smenochromene D (Likonide B). Synlett 36, 700–702 (2005). [DOI]


Malerich, J. P.; Trauner, D. Biomimetic Synthesis of Natural Products Isolated from Bignoniaceae in Strategies and Tactics in Organic Synthesis (Harmata, M., Ed.; Elsevier: Amsterdam, 2004; Vol. 5. pp 417-436).


Banghart, M.; Borges, K.; Isacoff, E. Y.; Trauner, D.; Kramer R. H. Light-Activated Ion Channels for Remote Control of Neuronal Firing. Nature Neuroscience 7, 1381–1386 (2004). [DOI]

Featured in Science: [DOI]


Hughes, C. C.; Trauner, D. Palladium-Catalyzed Couplings to Nucleophilic Heteroarenes: The Total Synthesis of (-)-Frondosin B. Tetrahedron 60, 9675–9686 (2004). [DOI]


Liang, G. X.; Trauner, D. Enantioselective Nazarov Reactions through Catalytic Asymmetric Proton Transfer. J. Am. Chem. Soc. 126, 9544–9545 (2004). [DOI]


Miller, A. K.; Byun, D. H.; Beaudry, C. M.; Trauner, D. The Total Synthesis of (–)-Crispatene. Proc. Natl. Acad. Sci. 101, 12019–12023 (2004). [DOI]


Trauner, D.; Kramer, R. H. Metabolic Modulation of Potassium Channels. Science STKE 233, pe22 (2004). [DOI]


Liang, G. X.; Gradl, S. N.; Trauner, D. Efficient Nazarov Cyclizations of 2-Alkoxy-1,4-pentadien-3-ones. Org. Lett. 5, 4931-4934 (2003). [DOI]


Trauner, D. Potassium Channels: Symmetric, Selective, and Sensitive. Angew. Chem., Int. Ed. 42, 5671–5675 (2003). [DOI]


Hughes, C. C.; Trauner, D. Direct Catalytic Asymmetric Amination of Aldehydes: Synthesis of Evans Oxazolidinones and α-Amino Acids. Chemtracts 16, 511–517 (2003). [DOI]


Miller, A. K.; Banghart, M. R.; Beaudry, C. M.; Suh, J. M.; Trauner, D. Development of Novel Lewis Acid Catalyzed Cycloisomerizations: Synthesis of Bicyclo[3.1.0]hexenes and Cyclopentenones. Tetrahedron 59, 8919–8930 (2003). [DOI]


Hughes, C. C.; Kennedy-Smith, J. J.; Trauner, D. Synthetic Studies toward the Guanacastepenes. Org. Lett. 5, 4113–4115 (2003). [DOI]


Gradl, S.; Felix, J. P.; Isacoff, E. Y.; Garcia, M. L.; Trauner, D. Protein Surface Recognition by Rational Design: Nanomolar Ligands for Potassium Channels. J. Am. Chem. Soc. 125, 12668–12669 (2003). [DOI]


Dorsey, A. D.; Barbarow, J. E.; Trauner, D. Reductive Cyclization of δ-Hydroxy Nitriles: A New Synthesis of Glycosylamines. Org. Lett. 5, 3237–3239 (2003). [DOI]


Malerich, J. P.; Trauner, D. Biomimetic Synthesis of (±)-Pinnatal and (±)-Sterekunthal A. J. Am. Chem. Soc. 125, 9554–9555 (2003). [DOI]


Ng, S. M.; Beaudry, C. M.; Trauner, D. Intramolecular Diels-Alder Reactions of 5-Vinyl-1 3-Cyclohexadienes. Org. Lett. 5, 1701–1704 (2003). [DOI]


Miller, A. K.; Trauner, D. Total Synthesis of (±)-Photodeoxytridachione through a Lewis Acid Catalyzed Cyclization. Angew. Chem., Int. Ed. 42, 549–552 (2003). [DOI]


Böhm, C.; Austin, W. F.; Trauner, D. Enzymatic Desymmetrization of a Centrosymmetric Diacetate. Tetrahedron: Asymmetry 14, 71–74 (2003). [DOI]


Hughes, C. C.; Trauner, D. The Total Synthesis of (–)-Amathaspiramide F. Angew. Chem., Int. Ed. 41, 4556–4559 (2002). [DOI]


Hughes, C. C.; Scharn, D.; Mulzer, J.; Trauner, D. Borane-Ammonia Complexes Stabilized by Hydrogen Bonding. Org. Lett. 4, 4109–4111 (2002). [DOI]


Beaudry, C. M.; Trauner, D. Synthetic Studies Toward SNF4435 C and SNF4435 D. Org. Lett. 4, 2221-2224 (2002). [DOI]


Hughes, C. C.; Trauner, D. Concise Total Synthesis of (–)-Frondosin B Using a Novel Palladium Catalyzed Cyclization. Angew. Chem., Int. Ed. 41, 1569–1642 (2002). [DOI]


Gradl, S. N.; Kennedy-Smith, J. J.; Kim, J.; Trauner, D A Practical Variant of the Claisen-Eschenmoser Rearrangement: Synthesis of Unsaturated Morpholine Amides. Synlett 3, 411–414 (2002). [DOI]


Chemler, S. R.; Trauner, D.; Danishefsky, S. J. The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study and Applications in Natural Product Synthesis. Angew. Chem., Int. Ed. 40, 4544–4568 (2001). [DOI]


Carson, M. W.; Kim, G.; Hentemann, M. F.; Trauner, D.; Danishefsky, S. J. Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid. Angew. Chem., Int. Ed. 40, 4450–4452 (2001). [DOI]


Trauner, D.; Danishefsky, S. J. On the Conformations of Halichlorine and the Pinnaic Acids: Nitrogen Inversion as a Possible Determinant of Biological Profile. Helv. Chim. Acta 83, 2344–2351 (2000). [DOI]


Danishefsky, S. J.; Inoue, M.; Trauner, D. Synthesis of Immunomodulatory Marine Natural Products in The Role of Natural Products in Drug Discovery (Ernst Schering Research Foundation (ESRF) Workshop 32, pp. 1-24, Heidelberg, New York: Springer 2000).


Novak, B. H.; Hudlicky, T.; Reed, J. W.; Mulzer, J.; Trauner, D. Morphine Synthesis and Biosynthesis - an Update. Curr. Org. Chem. 4, 343–362 (2000). [DOI]


Trauner, D.; Schwarz, J. B.; Danishefsky, S. J. Total Synthesis of (+)-Halichlorine, an Inhibitor of VCAM-1 Expression. Angew. Chem., Int. Ed. 38, 3542–3545 (1999). [DOI]


Trauner, D.; Danishefsky, S. J. Studies Towards the Total Synthesis of Halichlorine: Asymmetric Synthesis of the Spiroquinolizidine Subunit. Tetrahedron Lett. 40, 6513–6516 (1999). [DOI]


Porth, S.; Bats, J. W.; Trauner, D.; Giester, G.; Mulzer, J. Insight into the Mechanism of the Saegusa Oxidation: Isolation of a Novel Palladium(0) Tetraolefin Complex. Angew. Chem., Int. Ed. 38, 2015–2016 (1999). [DOI]


Mulzer, J.; Trauner, D. Practical Synthesis of (–)-Morphine. Chirality 11, 475–482 (1999). [DOI]


Mulzer, J., Schein, K.; Bohm, I.; Trauner, D. About the Use of Molecular Workbenches and Platforms in Organic Synthesis. Pure Appl. Chem. 70, 1487–1493 (1998).


Trauner, D.; Bats, J. W.; Werner, A.; Mulzer, J. Synthesis of Enantiomerically Pure Morphine Alkaloids: The Hydrophenanthrene Route. J. Org. Chem. 63, 5908–5918 (1998). [DOI]


Trauner, D.; Porth, S.; Opatz, T.; Bats, J. W.; Giester, G.; Mulzer, J. New Ventures in the Construction of Complex Heterocycles: Synthesis of Morphine and Hasubanan Alkaloids. Synthesis, 653–664 (1998). [DOI]


Mulzer, J.; Bats, J. W.; List, B.; Opatz, T.; Trauner, D. The Phenanthrenone Approach to Opium Alkaloids: Formal Total Synthesis of Morphine by Sigmatropic Rearrangement. Synlett 5, 441–444 (1997). [DOI]


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