Prof. Dr. Johannes Teichert, Institut für Chemie, TU Chemnitz

"Neutral Homoaromatic Hydrocarbons - A "first" in many ways"

Prof. Dr. Gerhard Sextl

Fraunhofer-Institut für Silicatforschung ISC

Lehrstuhl für Chemische Technologie der Materialsynthese

Julius-Maximilians-Universität Würzburg

title to be announced

Ass.-Prof. Gustav Oberdorfer

Graz University of Technology

Ideal is pretty, but irregular more interesting - functionalization of de novo designed proteins by deviating from ideal geometries

Tremendous progress has been made in protein design in part due to advances in machine learning and growth of protein structure databases. However, the ability to reliably introduce function into genetically encodable de novo proteins is still a challenging task. Among the plethora of protein functions, the introduction of catalytic functionality into de novo proteins has proven to be particularly hard. One of the bottlenecks in this endeavor is the limited variability of starting backbones. We recently found that it is possible to overcome this limitation by using machine learning approaches and parametric design. This enabled us to establish a general method for the de novo design of enzymes. Our show-case examples include designs with an activated lysine and metal cofactors of increasing complexity. In this talk, I will highlight our challenges and findings during the development of the design pipeline.

Prof. Dr. Verena Dirsch, Division of Pharmacognosy, Universität Wien

Nukleäre Rezeptoren als Targets für Naturstoffe und deren Analoga

Kirsten Jung, Ludwig-Maximilians-Universität

Mechanisms of Gram-negative bacteria to survive in acidic environments

Hybrid Information
Webinar link: https://mpi-biochemistry.zoom-x.de/j/64180753743
Password: 192953
Webinar ID: 641 8075 3743

Ass.-Prof. Dr. Davin Piercey
School of Mechanical Engineering, Purdue University, West Lafayette/USA

Nitrogen: innately sustainable chemistry enabled by an ubiquitous element