Activities in our daily life are mainly limited by the turnover rate of our biomolecular machines. After an extensive sports session, we need to regenerate our energy. In the process, enzymes in our cells replenish our stores of molecules such as ATP, and ion pumps transport potassium and sodium ions back into our muscle cells. To do this, these biomolecular machines often change their conformation. Although the reaction pathway of many biomolecular machines is known, it is very difficult to study the rate of change between two conformational states. Yet quantifying dynamic processes is essential to understanding many biological processes.
For the 17th time, the Römer Prizes for outstanding achievements in biochemistry and chemistry were awarded in December 2022.