Research interests
Prof. Dr. Biel
- Molecular analysis of signal transduction in photoreceptors and olfactory neurons
- Functional analysis of cyclic nucleotide-gated (CNG) cation channels in sensory and non-sensory cells
We study the physiological roles of proteins involved in sensory transduction of photoreceptors and olfactory neurons. Our major focus is on the role of cyclic nucleotide-gated (CNG) cation channels in the respective signaling pathways. We are also investigating retinal diseases caused by CNG channel dysfunction (e.g. total colorblindness and retinitis pigmentosa). To this end we use state-of-the-art molecular biology techniques, electrophysiology and gene-targeting in mice.
- Signal transduction pathways involved in the control of rhythmic processes
- Structure, function and regulation of pacemaker (HCN) channels in neurons and heart
We analyze the function and regulation of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. These channels play a key role in the control of the heart beat (“pacemaker channels”) and of network activity in thalamus and other parts of the CNS. Defects in HCN channel function are linked to a variety of diseases including cardiac dysrhythmia and absence epilepsy.