Selected publications
Selected reviews
Selected publications
Fenske S, Mader R, Scharr A, Paparizos C, Cao-Ehlker X, Michalakis S, Shaltiel L, Weidinger M, Stieber J, Feil S, Feil R, Hofmann F, Wahl-Schott C, Biel M. (2011) HCN3 contributes to the ventricular action potential waveform in the murine heart. Circ Res. 2011 Oct 14;109(9):1015-23. Epub 2011 Sep 8.
Becirovic E, Nakova K, Hammelmann V, Hennel R, Biel M, Michalakis S. (2010) The Retinitis Pigmentosa Mutation c.3444+1G>A in CNGB1 Results in Skipping of Exon 32. PLoS ONE 5(1): e8969. doi:10.1371/journal.pone.0008969
Griessmeier K, Cuny H, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C. Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels. J Biol Chem. 2009 Oct 23;284(43):29809-16. Epub 2009 Aug 28.
X. Zong, M. Schieder, H. Cuny, S. Fenske, C. Gruner, K. Rötzer, O. Griesbeck, H. Harz, M. Biel and C. Wahl-Schott (2009). The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Arch 2009 Sep;458(5):891-9. Epub 2009 Jun 26.
N. Tanimoto, R. L. Muehlfriedel, M. D. Fischer, E. Fahl, P. Humphries, M. Biel and M. W. Seeliger (2009) Vision tests in the mouse: Functional phenotyping with electroretinography. Front Biosci 14: 2730-7.
J. Trümpler, K. Dedek, T. Schubert, L. P. de Sevilla Müller, M. Seeliger, P. Humphries, M. Biel and R. Weiler. (2008). Rod and cone contributions to horizontal cell light responses in the mouse retina. J Neurosci 28(27): 6818-25.
Leinders-Zufall T, Cockerham RE, Michalakis S, Biel M, Garbers DL, Reed RR, Zufall F and Munger SD. Contribution of the receptor gyanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc Acad Aci USA 2007 104:14507-14512
Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L. Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine. Circulation. 2007 Feb 20;115(7):872-80.
Wahl-Schott C, Baumann L, Cuny H, Eckert C, Griessmeier K, Biel M. Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15657-62.
Michalakis S, Reisert J, Geiger H, Wetzel CH, Zong X, Bradley J, Spehr M, Huttl S, Gerstner A, Pfeifer A, Hatt H, Yau KW, Biel M. Loss of CNGB1 protein leads to olfactory dysfunction and subciliary CNG channel trapping. J Biol Chem. 2006 Nov 17;281(46):35156-66.
Mistrik P, Pfeifer A, Biel M. The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration. Pflugers Arch. 2006 Sep;452(6):718-27.
Haverkamp S, Michalakis S, Claes E, Seeliger MW, Humphries P, Biel M, Feigenspan A. Synaptic plasticity in CNGA3(-/-) mice: cone bipolar cells react on the missing cone input and form ectopic synapses with rods. J Neurosci. 2006 May 10;26(19):5248-55.
Zong X, Eckert C, Yuan H, Wahl-Schott C, Abicht H, Fang L, Li R, Mistrik P, Gerstner A, Much B, Baumann L, Michalakis S, Zeng R, Chen Z, Biel M (2005) A novel mechansim of modulation of hyperpolarization-activated cyclic-nucleotide-gated channels by Src kinase. J. Biol. Chem.. 2005 Oct 7;280(40):34224-32
Mistrík P, Mader R, Michalakis S, Weidinger M, Pfeifer A, Biel M (2005) The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic AMP. J. Biol. Chem. 280:27056-27061
Michalakis S, Geiger H, Haverkamp S, Hofmann F, Gerstner A, Biel M (2005) Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3. Invest. Ophthalmol. Vis. Sci 46:1516-1524
Wahl-Schott C, Baumann L, Zong X, Biel M (2005) An arginine in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels. J. Biol. Chem. 280: 13694-13700.
Hüttl S, Michalakis S, Seeliger S, Luo D, Acar N, Geiger H, Hudl K, Mader R, Haverkamp S, Moser M, Pfeifer A, Gerstner A, Yau KW, Biel M (2005) Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. J. Neurosci. 25:130-138.
Baumann L, Gerstner A, Zong X, Biel M, Wahl-Schott, C (2004) Functional characterization of the L-type Ca2+ channel Cav1.4a1 from mouse retina. Invest. Ophtahlmol. Vis. Sci. 45: 708-713.
Stieber J, Herrmann S, Susanne Feil S, Löster L, Feil R, Biel M, Hofmann F, and Ludwig A (2003) The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc. Natl. Acad. Sci. USA. 100:15235-15240
Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M (2003) Role of subunit heteromerization and N-linked glycosylation in the formation of functional HCN channels. J. Biol. Chem. 278:43781-43786.
Hattar S, Lucas RJ, Mrosovsky N, Thompson S, Douglas RH. Hankins MW, Lem J, Biel M , Hofmann F, Foster RG, Yau KW (2003) Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature:424:75-81
Ludwig A, Budde T, Stieber J, Moosmang S, Wahl C, Holthoff K, Langebartels A, Wotjak C, Munsch T, Zong X, Feil S, Feil R, Lancel M, Chien KR, Konnerth A, Pape HC, Biel M, Hofmann F. (2003) Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J 15:216-224
Er F, Larbig R, Ludwig A, Biel M, Hofmann F, Beuckelmann DJ, Hoppe UC. (2003) Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes. Circulation. 107:485-489
Seeliger M, Grimm C, Stahlberg F, Friedburg C, Jaissle G, Zrenner E, Guo H, Remé C, Humphries P, Hofmann F, Biel M, Fariss RN, Redmond TM, Wenzel A (2001) New views on RPE65 deficiency: The rod system is the source of vision in a mouse model of Lebers congenital amaurosis. Nature Genet 29:70-74
Freichel M, Suh SH, Pfeifer A, Schweig U, Trost C, Weißgerber P, Biel M, Philipp S, Freise D, Droogmans G, Hofmann F, Flockerzi V, Nilius B (2001) Lack of an endothelial store-operated Ca2+-current impairs agonist-dependent vasorelaxation in TRP4-/- mice Nature Cell Biol 3:121-127
Zong X, Stieber J, Ludwig A, Hofmann F, Biel M (2001) A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2. J Biol Chem 276:6313-6319
Gerstner A, Zong X, Hofmann F, Biel M (2000) Molecular cloning and functional characterization of a new modulatory CNG channel subunit from mouse retina. J Neurosci 20:1324-1332
Biel M, Seeliger M, Pfeifer A, Kohler K, Gerstner A, Ludwig A, Jaissle G, Fauser S, Zrenner E, Hofmann F. (1999) Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci USA 96:7553-7557
Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. Nature 393:587-591
Selected reviews
Biel M, Wahl-Schott C, Michalakis S, Zong X (2009) Hyperpolarization-activated cation channels: from gene to function. Physiol Rev 89:847-85
Biel M (2009) Cyclic nucleotide-regulated cation channels. J Biol Chem. 284:9017-9021
Biel M, Michalakis S (2009) Cyclic nucleotide-gated channels. Handb Exp Pharmacol 191:111-36
Biel M, Michalakis S (2007) Function and dysfunction of CNG channels: insights from channelopathies and mouse models. Mol Neurobiol 35:266-277