Postsynthetic modification of an amino-tagged
MOF using peptide coupling reagents:
a comparative study
The suitability of four peptide coupling reagents for postsynthetic modification (PSM) of amino-tagged metal–organic frameworks (MOFs) with carboxylic acids was investigated. Mild reaction conditions at room temperature allow effective covalent attachment of drugs and biomolecules inside the pores of MOFs with moderate chemical stability.