Dr. Martin Sikor
Research Interests
I am interested in the application of various single molecule fluorescence techniques to study protein folding and the role of molecular chaperones. More specifically, I have used spFRET experiments to study the conformational dynamics of the major mitochondrial Heat Shock Protein 70. To follow the dynamics on different timescales, I have performed spFRET burst analysis measurements using multiparameter detection and pulsed interleaved excitation, as well as spFRET TIRF experiments. Additionally, I am interested in the role of the chaperonin GroEL in protein folding.
Curriculum Vitae
| Jan. 08 - | PhD student in Don Lamb's group. LMU, Munich. |
| Jan. 07 - Mar. 07 | Research assistant at Dr. Barbara Frisken's lab, Simon Fraser University, Vancouver, Canada. |
| Dec. 05 - Apr. 07 | Diploma thesis at the Chair for Experimental Physics 1, Prof. Achim Wixforth: "Diffusion and propagation in supported lipid bilayers" |
| Oct. 01 - Apr. 07 | Studies in physics, Universität Augsburg, Germany |
Publications
- Chakraborty K., Chatila M., Sinha J., Shi Q., Poschner B.C., Sikor M., Jiang G., Lamb D.C., Hartl F.U. and Hayer-Hartl M., Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding (2010), Cell, 142(1), 112-122.
- Sikor M., Sabin J., Keyvanloo A., Schneider M.F., Thewalt J.L., Bailey A.E. and Frisken B.J., Interaction of a Charged Polymer with Zwitterionic Lipid Vesicles (2010), Langmuir, 26(6), 4095-4102.
- Mapa K., Sikor M., Kudryavtsev V., Waegemann K., Kalinin S., Seidel C.A.M., Neupert N., Lamb D.C. and Mokranjac D., The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone (2010), Molecular Cell, 38(1), 89-100.
- Griepernau, B., Leis, S., Schneider, M.F., Sikor, M., Steppich, D., Böckmann, R., 1-Alkanols and membranes - a story of attraction, Biochim. Biophys. Acta (2007), doi:10.1016/j.bbamem.2007.08.002.
- Bismuto E., Di Maggio E., Pleus S., Sikor M., Röcker C., Nienhaus G.U. and Lamb D.C., Molecular dynamics simulation of the acidic compact state of apomyoglobin from yellowfin tuna (2008), Proteins: Structure, Function, and Bioinformatics,74(2), 273-290.
Contact
- Chakraborty K., Chatila M., Sinha J., Shi Q., Poschner B.C., Sikor M., Jiang G., Lamb D.C., Hartl F.U. and Hayer-Hartl M., Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding (2010), Cell, 142(1), 112-122.
- Sikor M., Sabin J., Keyvanloo A., Schneider M.F., Thewalt J.L., Bailey A.E. and Frisken B.J., Interaction of a Charged Polymer with Zwitterionic Lipid Vesicles (2010), Langmuir, 26(6), 4095-4102.
- Mapa K., Sikor M., Kudryavtsev V., Waegemann K., Kalinin S., Seidel C.A.M., Neupert N., Lamb D.C. and Mokranjac D., The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone (2010), Molecular Cell, 38(1), 89-100.
- Griepernau, B., Leis, S., Schneider, M.F., Sikor, M., Steppich, D., Böckmann, R., 1-Alkanols and membranes - a story of attraction, Biochim. Biophys. Acta (2007), doi:10.1016/j.bbamem.2007.08.002.
- Bismuto E., Di Maggio E., Pleus S., Sikor M., Röcker C., Nienhaus G.U. and Lamb D.C., Molecular dynamics simulation of the acidic compact state of apomyoglobin from yellowfin tuna (2008), Proteins: Structure, Function, and Bioinformatics,74(2), 273-290.
Contact
Room: E1.003
Tel.: +49 (0) 89 2180-77537
E-Mail: Martin.Sikor"at"cup.uni-muenchen.de