Nucleic acid based therapeutics

• Development of nonviral vectors
  • Intracellular fate of polyplexes
  • purification of polyplexes
  • biodegradable polycations
  • bioresponsive polyplexes
  • peptide enhanced DNA and RNA delivery
• Targeting Strategies
  • Receptor-ligand interaction
  • transcriptional targeting
  • physical targeting
    • Locoregional Hyperthermia
    • Photo Chemical Internalization (PCI)

Therapeutic Strategies

• Synthetic double stranded RNA for Glioblastoma treatment
• Tumor Angiogenesis
• Culture Models of Colorectal Cancer