PD Dr. Armin R. Ofial
Dipl.-Ing., Dr.-Ing.
Akad. Dir.

Dept. Chemie
Ludwig-Maximilians-Universität München 
Butenandtstr. 5-13 (Haus F) 
81377 München

Telefon: +49 (0)89 2180 77715 
Fax:      +49 (0)89 2180 9977715 


Master Chemie

WiSe 2017/18: Physikalisch-Organische Chemie (Vorlesung)
(ab 12.10.2017: LogIn mit Campuskennung! Einschreibeschlüssel: 2017poc)

SoSe 2017: Heterocyclen und Naturstoffe
(LogIn mit Campuskennung! Einschreibeschlüssel: 2017het)

Nebenfach Chemie

WiSe 2004/05 bis WiSe 2015/16:
Vorlesung Chemie für Human- und Zahnmediziner
Research Team
Artem Leonov (since 2013) [more]
Elija Wiedemann (2011-2016) [more]
former members Dr. Alexander Wagner (2010-2015) [more]
Dr. Wei Han (2008-2011) [more]
Research Network
  Physical Organic Chemistry and C-H Functionalization  
74.* Solvatation als Ursache für die unerwartete Nucleophilie-Reihung von Peroxid-Anionen
Solvation Accounts for the Counter-Intuitive Nucleophilicity Ordering of Peroxide Anions

R. J. Mayer, T. Tokuyasu, P. Mayer, J. Gomar, S. Sabelle, B. Mennucci,* H. Mayr,* A. R. Ofial,*
Angew. Chem. 2017, 129, 13463-13467.
Angew. Chem. Int. Ed. 2017, 56, 13279-13282.
73.* Quantification and Theoretical Analysis of the Electrophilicities of Michael Acceptors

D. S. Allgäuer, H. Jangra, H. Asahara, Z. Li, Q. Chen, H. Zipse,* A. R. Ofial,* H. Mayr,*
J. Am. Chem. Soc. 2017, 139, 13318-13329.
72. Nucleophilicities and Lewis Basicities of Sterically Hindered Pyridines E. Follet, H. Zipse, S. Lakhdar, A. R. Ofial, G. Berionni,
Synthesis 2017, 49, 3495-3504.
71. Reactivity-Tuning in Frustrated Lewis Pairs: Nucleophilicity and Lewis Basicity of Sterically Hindered Phosphines E. Follet, P. Mayer, D. S. Stephenson, A. R. Ofial, G. Berionni,
Chem. Eur. J. 2017, 23, 7422-7427.
70. Philicity, Fugality, and Equilibrium Constants: When Do Rate-Equilibrium Relationships Break Down? H. Mayr, A. R. Ofial,
Pure Appl. Chem. 2017, 89, 729-744.
69. Nucleophilic Reactivities of Bis-Acceptor-Substituted Benzyl Anions Á. Puente, A. R. Ofial, H. Mayr,
Eur. J. Org. Chem. 2017, 1196-1202.
68. Nucleophilicity Parameters of Stabilized Iodonium Ylides for Characterizing their Synthetic Potential S. Chelli, K. Troshin, P. Mayer, S. Lakhdar, A. R. Ofial, H. Mayr,
J. Am. Chem. Soc. 2016, 138, 10304-10313.
67. Philicities, Fugalities, and Equilibrium Constants H. Mayr, A. R. Ofial,
Acc. Chem. Res. 2016, 49, 952-965. [Open Access]
66. Nucleophilic Reactivities of 2-Substituted Malonates Á. Puente, S. He, F. Corral-Bautista, A. R. Ofial, H. Mayr,
Eur. J. Org. Chem. 2016, 1841-1848.
65.* Sequential Oxidative α-Cyanation/Anti-Markovnikov Hydroalkoxylation of Allylamines

A. Wagner, N. Hampel, H. Zipse, A. R. Ofial,*
Org. Lett. 2015, 17, 4770-4773.
64. A Quantitative Approach to Polar Organic Reactivity H. Mayr, A. R. Ofial,
SAR and QSAR in Environmental Research 2015, 26, 619-646.
63.* Kinetic and Theoretical Studies of Beta-Lactone Reactivity - A Quantitative Scale for Biological Application E. N. Wiedemann, F. A. Mandl, I. D. Blank, C. Ochsenfeld,* A. R. Ofial,* S. A. Sieber,*
ChemPlusChem 2015, 80, 1673-1679.
62.* Benzhydrylium and Tritylium Ions: Complementary Probes for Examining Ambident Nucleophiles A. R. Ofial,*
Pure Appl. Chem. 2015, 87, 341-351.
61.* Potassium Thiocyanate as Source of Cyanide for the Oxidative α-Cyanation of Tertiary Amines
A. Wagner, A. R. Ofial,*
J. Org. Chem. 2015, 80, 2848-2854.
60. Feineinstellung der nucleophilen Reaktivität von Bor-at-Komplexen aus Aryl- und Heteroarylboronsäureestern
Fine-Tuning of the Nucleophilic Reactivities of Boron-Ate Complexes Derived From Aryl and Heteroaryl Boronic Esters
G. Berionni, A. I. Leonov, P. Mayer, A. R. Ofial, H. Mayr,
Angew. Chem. 2015, 127, 2820-2824.
Angew. Chem. Int. Ed. 2015, 54, 2780-2783.
59. Scales of Lewis Basicities toward C-centered Lewis Acids (Carbocations) H. Mayr, J. Ammer, M. Baidya, B. Maji, T. A. Nigst, A. R. Ofial, T. Singer,
J. Am. Chem. Soc. 2015, 137, 2580-2599. [Open Access]
58. Structures and Reactivities of 2-Trityl- and 2-(Triphenylsilyl)pyrrolidine-Derived Enamines: Evidence for Negative Hyperconjugation with the Trityl Group H. Erdmann, F. An, P. Mayer, A. R. Ofial, S. Lakhdar, H. Mayr,
J. Am. Chem. Soc. 2014, 136, 14263-14269.
57.* Di- and Triarylmethylium Ions as Probes for the Ambident Reactivities of Carbanions Derived from 5-Benzylated Meldrum’s Acid X. Chen, Y. Tan, G. Berionni, A. R. Ofial,* H. Mayr,
Chem. Eur. J. 2014, 20, 11069-11077.
56. Structures and Reactivities of Iminium Ions Derived From Substituted Cinnamaldehydes and Various Chiral Imidazolidin-4-ones F. An, S. Paul, J. Ammer, A. R. Ofial, P. Mayer, S. Lakhdar, H. Mayr,
Asian J. Org. Chem. 2014, 3, 550-555.
55.* Iron-Catalyzed Generation of α-Amino Nitriles from Tertiary Amines

A. Wagner, W. Han, P. Mayer, A. R. Ofial,*
Adv. Synth. Catal. 2013, 355, 3058-3070.
54. Nucleophilic Reactivities and Lewis Basicities of 2-Imidazolines and Related N-Heterocyclic Compounds B. Maji, M. Baidya, J. Ammer, S. Kobayashi, P. Mayer, A. R. Ofial, H. Mayr,
Eur. J. Org. Chem. 2013, 3369-3377.
53.* Towards a Comprehensive Hydride Donor Ability Scale M. Horn, L. H. Schappele, G. Lang-Wittkowski, H. Mayr, A. R. Ofial,*
Chem. Eur. J. 2013, 19, 249-263.
52. A quantitative approach to nucleophilic organocatalysis H. Mayr, S. Lakhdar, B. Maji, A. R. Ofial,
Beilstein J. Org. Chem. 2012, 8, 1458-1478.
51.* No Detours: Palladium-Catalyzed Oxidative C-H/C-H Cross-Couplings of Heteroarenes

W. Han, A. R. Ofial,*
Synlett 2011, 1951-1955.
50.* Palladium-Catalyzed Direct Arylations of Azoles with Aryl Silicon and Tin Reagents

W. Han, P. Mayer, A. R. Ofial,*
Chem. Eur. J. 2011, 17, 6904-6908.
49.* Palladium-katalysierte dehydrierende Kreuzkupplung von Benzazolen mit Azolen
Palladium-Catalyzed Dehydrogenative Cross Couplings of Benzazoles with Azoles

W. Han, P. Mayer, A. R. Ofial,*
Angew. Chem. 2011, 123, 2226-2230;
Angew. Chem. Int. Ed. 2011, 50, 2178-2182.
48. Abschied vom HSAB-Modell ambidenter Reaktivität
Farewell to the HSAB Treatment of Ambident Reactivity
H. Mayr, M. Breugst, A. R. Ofial,
Angew. Chem. 2011, 123, 6598-6634;
Angew. Chem. Int. Ed. 2011, 50, 6470-6505.
47. The Origin of Ultrafast Proton Transfer: Multidimensional Wave Packet Motion vs. Tunneling C. Schriever, S. Lochbrunner, A. R. Ofial, E. Riedle,
Chem. Phys. Lett. 2011, 503, 61-65.
46.* Electrophilic Reactivities of 1,2-Diaza-1,3-dienes T. Kanzian, S. Nicolini, L. De Crescentini, O. A. Attanasi,* A. R. Ofial,* H. Mayr,
Chem. Eur. J. 2010, 16, 12008-12016.
45.* Iron-Catalyzed Oxidative Mono- and Bis-Phosphonation of N,N-Dialkylanilines

W. Han, P. Mayer, A. R. Ofial,*
Adv. Synth. Catal. 2010, 352, 1667-1676.
44. Reactivity Parameters for Rationalizing Iminium-Catalyzed Reactions S. Lakhdar, A. R. Ofial, H. Mayr,
J. Phys. Org. Chem. 2010, 23, 886-892.
43. trans-1-Phenylpyrrolidine-2,5-dicarbonitrile W. Han, A. R. Ofial, P. Mayer,
Acta Crystallogr., Sect. E: Struct. Rep. Online 2010, 66, o397.
42.* Iron catalyzed dehydrogenative phosphonation of N,N-dimethylanilines W. Han, A. R. Ofial,*
Chem. Commun. 2009, 6023-6025.
41.* Iron catalyzed oxidative cyanation of tertiary amines W. Han, A. R. Ofial,*
Chem. Commun. 2009, 5024-5026.
40. 4-[4-(Dimethylamino)benzylidene]-2,6-dimethylcyclohexa-2,5-dienone N. Hampel, D. Richter, A. R. Ofial, H. Mayr, P. Mayer,
Acta Crystallogr., Sect. E: Struct. Rep. Online 2009, 65, o2102.
39. Can One Predict Changes from SN1 to SN2 Mechanisms? T. B. Phan, C. Nolte, S. Kobayashi, A. R. Ofial, H. Mayr, 
J. Am. Chem. Soc. 2009, 131, 11392-11401.
38. Synthesis and Characterization of Novel Quinone Methides: Reference Electrophiles for the Construction of Nucleophilicity Scales  D. Richter, N. Hampel, T. Singer, A. R. Ofial, H. Mayr,
Eur. J. Org. Chem. 2009, 3203-3211.
37. How To Predict Changes in Solvolysis Mechanisms H. Mayr, A. R. Ofial,
Pure Appl. Chem. 2009, 81, 667-683.
36. Und es geht doch: Nucleophilieskalen für die Syntheseplanung H. Mayr, A. R. Ofial,
Nachr. Chem. 2008, 56, 871-877.
35. Nucleophilic Reactivities of Pyrroles  T. A. Nigst, M. Westermaier, A. R. Ofial, H. Mayr,
Eur. J. Org. Chem. 2008, 2369-2374.
34. Do General Nucleophilicity Scales Exist? H. Mayr, A. R. Ofial,
J. Phys. Org. Chem. 2008, 21, 584-595.
33. Inverse Solvent Effects in Carbocation Carbanion Combination Reactions: The Unique Behavior of Trifluoromethylsulfonyl Stabilized Carbanions S. T. A. Berger, A. R. Ofial, H. Mayr,
J. Am. Chem. Soc. 2007, 129, 9753-9761.
32. Nucleophilic Reactivities of Indoles S. Lakhdar, M. Westermaier, F. Terrier, R. Goumont, T. Boubaker, A. R. Ofial, H. Mayr,
J. Org. Chem. 2006, 71, 9088-9095.
31. Das Reaktivitäts-Selektivitäts-Prinzip: ein unzerstörbarer Mythos der organischen Chemie
The Reactivity-Selectivity Principle: An Imperishable Myth in Organic Chemistry 
H. Mayr, A. R. Ofial,
Angew. Chem. 2006, 118, 1876-1886;
Angew. Chem. Int. Ed. 2006, 45, 1844-1854.
30. How Fast Do R-X Bonds Ionize?- A Semiquantitative Approach B. Denegri, A. R. Ofial, S. Juric, A. Streiter, O. Kronja, H. Mayr,
Chem. Eur. J. 2006, 12, 1657-1666.
29. Kinetics of the Solvolyses of Benzhydryl Derivatives: Basis for the Construction of a Comprehensive Nucleofugality Scale B. Denegri, A. Streiter, S. Juric, A. R. Ofial, O. Kronja, H. Mayr,
Chem. Eur. J. 2006, 12, 1648-1656; 5415.
28. Quantification of the β-Stabilizing Effect of the Dicarbonyl(η5-cyclopentadienyl)iron Group F. Dulich, K.-H. Müller, A. R. Ofial, H. Mayr,
Helv. Chim. Acta 2005, 88, 1754-1768.
27. Kinetics of Electrophile-Nucleophile Combinations: A General Approach to Polar Organic Reactivity H. Mayr, A. R. Ofial
Pure Appl. Chem. 2005, 77, 1807-1821.
26. The Propagation Rate of the Cationic Polymerization of 2,4,6-Trimethylstyrene: A Linear Free Energy Approach H. Mayr, A. R. Ofial, H. Schimmel, 
Macromolecules 2005,38, 33-40.
25. Determination of Rate Constants in the Carbocationic Polymerization of Styrene: Effect of Temperature, Solvent Polarity, and Lewis Acid P. De, R. Faust, H. Schimmel, A. R. Ofial, H. Mayr,
Macromolecules 2004, 37, 4422-4433.
24. Stereoselective synthesis of cis-fused hexahydro-isoindolones S. Rehn, A. R. Ofial, K. Polborn, H. Mayr, 
ARKIVOC 2004 (iii), 120-131.
23. Reactivities of Carbocations and Carbanions A. R. Ofial, H. Mayr, 
Macromol. Symp. 2004, 215, 353-367.
22. Electrophilicity Scales for Carbocations H. Mayr, A. R. Ofial 
in Carbocation Chemistry (G. A. Olah, G. K. S. Prakash, Eds.); Wiley: Hoboken, NJ, 2004; Chapter 13, pp 331-358.
21. Synthesis of Allylamines from Alkynes and Iminium Ions S. Rehn, A. R. Ofial, H. Mayr,
Synthesis 2003, 1790-1796.
20. Role of Electron Transfer Processes in Reactions of Diarylcarbenium Ions and Related Quinone Methides with Nucleophiles A. R. Ofial, K. Ohkubo, S. Fukuzumi, R. Lucius, H. Mayr,
J. Am. Chem. Soc. 2003, 125, 10906-10912.
19. Structure-Nucleophilicity Relationships for Enamines B. Kempf, N. Hampel, A. R. Ofial, H. Mayr,
Chem. Eur. J. 2003, 9, 2209-2218.
18. 5-Methoxyfuroxano[3,4-d]pyrimidine: a highly reactive neutral electrophile G. Ya. Remennikov, B. Kempf, A. R. Ofial, K. Polborn, H. Mayr,
J. Phys. Org. Chem.2003, 16, 431-437.
17. p-Nucleophilicity in Carbon-Carbon Bond Forming Reactions H. Mayr, B. Kempf, A. R. Ofial, 
Acc. Chem. Res. 2003, 36, 66-77.
16. Determination of the electrophilic reactivities of 1,1,3-triarylallyl cations H. Mayr, C. Fichtner, A. R. Ofial, 
J. Chem. Soc., Perkin Trans. 2 2002, 1435-1440.
15. Initiation and Propagation Rate Constants for the Cationic Polymerization of N-Vinylcarbazole H. Schimmel, A. R. Ofial, H. Mayr, 
Macromolecules 2002, 35, 5454-5458.
14. Reactions of Carbocations with Unsaturated Hydrocarbons: Electrophilic Alkylation or Hydride Abstractions? H. Mayr, G. Lang, A. R. Ofial, 
J. Am. Chem. Soc. 2002, 124, 4076-4083.
13. Wegweiser im Dschungel Organischer Reaktivität H. Mayr, A. R. Ofial, 
Einsichten - Forschung an der LMU München 2001, 20, 30-33. 
12. Reference Scales for the Characterization of Cationic Electrophiles and Neutral Nucleophiles H. Mayr, T. Bug, M. F. Gotta, N. Hering, B. Irrgang, B. Janker, B. Kempf, R. Loos, A. R. Ofial, G. Remennikov, H. Schimmel, 
J. Am. Chem. Soc. 2001, 123, 9500-9512.
11. Reactions of Carbon Electrophiles with Cobalt-Coordinated Enynes: Scope and Limitations H. Mayr, O. Kuhn, C. Schlierf, A. R. Ofial,
Tetrahedron 2000, 56, 4219-4229.
10. [2++4] Cycloadditions of Iminium Ions - Concerted or Stepwise Mechanism of Aza Diels-Alder Reactions? H. Mayr, A. R. Ofial, J. Sauer, B. Schmied, 
Eur. J. Org. Chem. 2000, 2013-2020.
9. Comparison of the Electrophilicities of the Free
and the (Tricarbonyl)iron-Coordinated Tropylium Ion
H. Mayr, K.-H. Müller, A. R. Ofial, M. Bühl,
J. Am. Chem. Soc. 1999, 121, 2418-2424.
8. Reactivities and Selectivities of Free and Metal-Coordinated Carbocations H. Mayr, M. Patz, M. F. Gotta, A. R. Ofial, 
Pure Appl. Chem. 1998, 70, 1993-2000.
7. NMR Spectroscopic Evidence for the Structure of Iminium Ion Pairs H. Mayr, A. R. Ofial, E.-U. Würthwein, N. C. Aust, 
J. Am. Chem. Soc. 1997, 119, 12727-12733.
6. Electrophilicities of Iminium Ions H. Mayr, A. R. Ofial,
Tetrahedron Lett.1997, 38, 3503-3506.
5. A Novel Pentaannulation Reaction of Iminium Ions A. R. Ofial, H. Mayr, 
Liebigs Ann. 1997, 333-335.
4. X-ray and 35Cl NQR Studies on the Trichloroacetyl Group in Covalent and Ionic Compounds of L-Valine and DL-Valine A. R. Ofial, S.-q. Dou, V. G. Krishnan, H. Paulus, H. Fuess, Al. Weiss, 
Z. Naturforsch. A 1997, 52, 249-258.
3. En-Reaktionen von Alkinen zur stereoselektiven Synthese von Allylaminen 
Ene Reactions of Alkynes for the Stereoselective Synthesis of Allylamines 
A. R. Ofial, H. Mayr, 
Angew. Chem. 1997, 109, 145-147; 
Angew. Chem. Int. Ed. Engl. 1997, 36, 143-145.
2. Reactions of Allylsilanes with Iminium Salts: Ene Reactions with Inverse Electron Demand  A. R. Ofial, H. Mayr, 
J. Org. Chem.1996, 61, 5823-5830.
1. N-Trichloro- and dichloroacetyl amino acids and compounds of amino acids with halogeno acetic acids: 35Cl nuclear quadrupole resonance spectroscopy; crystal structure of N-trichloroacetyl-glycine, -DL-alanine, and -L-alanine S.-q. Dou, A. Kehrer, A. R. Ofial,  Al. Weiss, 
J. Mol. Struct. 1995, 345, 11-29.